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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGB1
All Species:
44.85
Human Site:
Y155
Identified Species:
75.9
UniProt:
P09429
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09429
NP_002119.1
215
24894
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Chimpanzee
Pan troglodytes
Q9N1Q7
215
24747
Y184
A
A
K
L
K
E
K
Y
K
K
D
I
A
A
C
Rhesus Macaque
Macaca mulatta
XP_001102554
215
24881
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Dog
Lupus familis
XP_543194
210
24144
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Cat
Felis silvestris
Mouse
Mus musculus
P30681
210
24143
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Rat
Rattus norvegicus
P63159
215
24875
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508702
215
24789
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Chicken
Gallus gallus
P26584
207
23809
Y155
A
A
K
L
K
E
K
Y
E
K
D
I
A
A
Y
Frog
Xenopus laevis
NP_001080836
211
24437
Y155
A
A
K
L
K
E
K
Y
E
K
D
V
A
A
Y
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24537
393
44916
Y331
A
E
R
D
K
A
R
Y
E
R
E
M
T
E
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09390
235
27301
Y195
A
Q
A
D
K
D
R
Y
A
D
E
M
R
N
Y
Sea Urchin
Strong. purpuratus
P40644
200
22815
Y160
A
A
K
D
K
E
R
Y
I
K
A
M
A
E
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P27347
157
17127
E128
P
A
K
E
E
E
E
E
D
E
E
E
S
D
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11632
93
10784
P64
E
K
W
K
A
L
T
P
E
E
K
Q
P
Y
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.3
99
80.9
N.A.
80.4
99
N.A.
93.9
78.1
85.5
N.A.
N.A.
26.7
N.A.
34
47.9
Protein Similarity:
100
73.4
99.5
87.9
N.A.
87.4
100
N.A.
98.1
85.5
93.4
N.A.
N.A.
38.9
N.A.
50.6
60
P-Site Identity:
100
86.6
100
100
N.A.
100
100
N.A.
100
100
93.3
N.A.
N.A.
33.3
N.A.
26.6
60
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
100
100
100
N.A.
N.A.
66.6
N.A.
53.3
73.3
Percent
Protein Identity:
N.A.
35.3
N.A.
N.A.
20
N.A.
Protein Similarity:
N.A.
48.3
N.A.
N.A.
29.3
N.A.
P-Site Identity:
N.A.
20
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
60
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
86
79
8
0
8
8
0
0
8
0
8
0
72
65
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
22
0
8
0
0
8
8
65
0
0
8
0
% D
% Glu:
8
8
0
8
8
79
8
8
72
15
22
8
0
15
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
58
0
0
0
% I
% Lys:
0
8
79
8
86
0
65
0
8
72
8
0
0
0
8
% K
% Leu:
0
0
0
65
0
8
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
22
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
8
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
8
0
0
0
22
0
0
8
0
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
86
0
0
0
0
0
8
79
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _