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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
39.09
Human Site:
S130
Identified Species:
71.67
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
S130
R
K
K
G
N
F
V
S
P
V
K
N
Q
G
A
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
S130
R
K
K
G
N
F
V
S
P
V
K
N
Q
G
A
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
S130
R
K
K
G
N
F
V
S
P
V
K
N
Q
G
A
Dog
Lupus familis
XP_536212
304
34067
T115
S
C
W
T
F
S
T
T
G
A
L
E
S
A
I
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
S128
R
K
K
G
N
V
V
S
P
V
K
N
Q
G
A
Rat
Rattus norvegicus
P00786
333
37086
S128
R
K
K
G
N
V
V
S
P
V
K
N
Q
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
T200
W
R
D
H
G
Y
V
T
P
V
K
N
Q
G
H
Chicken
Gallus gallus
Q90686
334
37200
T133
W
R
R
K
G
Y
V
T
P
V
K
D
Q
G
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
T125
R
T
K
G
H
Y
I
T
D
V
K
N
Q
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
T167
W
R
T
K
G
A
V
T
A
V
K
D
Q
G
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
S153
W
R
E
E
G
I
V
S
P
V
K
N
Q
G
H
Maize
Zea mays
Q10717
360
39181
S156
W
R
E
D
G
I
V
S
P
V
K
N
Q
G
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
S154
W
R
E
D
G
I
V
S
P
V
K
E
Q
G
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
93.3
93.3
N.A.
46.6
40
N.A.
53.3
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
66.6
73.3
N.A.
80
N.A.
53.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
53.3
53.3
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
66.6
66.6
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
8
8
0
0
0
8
39
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
16
0
0
0
0
8
0
0
16
0
0
0
% D
% Glu:
0
0
24
8
0
0
0
0
0
0
0
16
0
0
0
% E
% Phe:
0
0
0
0
8
24
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
47
47
0
0
0
8
0
0
0
0
93
0
% G
% His:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
39
% H
% Ile:
0
0
0
0
0
24
8
0
0
0
0
0
0
0
8
% I
% Lys:
0
39
47
16
0
0
0
0
0
0
93
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
39
0
0
0
0
0
0
70
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
77
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
93
0
8
% Q
% Arg:
47
47
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
8
0
62
0
0
0
0
8
0
0
% S
% Thr:
0
8
8
8
0
0
8
39
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
16
85
0
0
93
0
0
0
0
0
% V
% Trp:
47
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
24
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _