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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
23.94
Human Site:
S271
Identified Species:
43.89
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
S271
T
G
I
Y
S
S
T
S
C
H
K
T
P
D
K
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
S271
T
G
I
Y
S
S
T
S
C
H
K
T
P
D
K
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
S271
T
G
I
Y
S
S
T
S
C
H
K
T
P
D
K
Dog
Lupus familis
XP_536212
304
34067
K243
Y
S
S
T
S
C
H
K
T
P
D
K
V
N
H
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
S269
S
G
V
Y
S
S
K
S
C
H
K
T
P
D
K
Rat
Rattus norvegicus
P00786
333
37086
S269
S
G
V
Y
S
S
N
S
C
H
K
T
P
D
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
S345
I
F
Y
E
P
K
C
S
S
E
R
L
N
H
A
Chicken
Gallus gallus
Q90686
334
37200
D271
Y
S
R
G
V
Y
Y
D
T
G
C
N
P
E
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
E266
D
G
I
Y
T
S
T
E
C
H
N
T
T
D
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
P308
S
E
G
V
Y
N
E
P
Q
C
D
A
Q
N
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
T294
E
G
V
Y
T
T
S
T
C
G
S
T
P
M
D
Maize
Zea mays
Q10717
360
39181
H297
S
G
V
Y
T
S
D
H
C
G
T
T
P
M
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
T295
K
G
V
F
T
S
N
T
C
G
N
T
P
M
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
80
80
N.A.
6.6
6.6
N.A.
60
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
93.3
93.3
N.A.
13.3
13.3
N.A.
66.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
33.3
40
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
66.6
60
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
8
8
0
70
8
8
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
8
8
0
0
16
0
0
47
24
% D
% Glu:
8
8
0
8
0
0
8
8
0
8
0
0
0
8
0
% E
% Phe:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
70
8
8
0
0
0
0
0
31
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
8
0
47
0
0
0
8
8
% H
% Ile:
8
0
31
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
0
0
0
0
8
8
8
0
0
39
8
0
0
39
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
24
8
% M
% Asn:
0
0
0
0
0
8
16
0
0
0
16
8
8
16
8
% N
% Pro:
0
0
0
0
8
0
0
8
0
8
0
0
70
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
31
16
8
0
47
62
8
47
8
0
8
0
0
0
0
% S
% Thr:
24
0
0
8
31
8
31
16
16
0
8
70
8
0
0
% T
% Val:
0
0
39
8
8
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
8
62
8
8
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _