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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSH All Species: 22.42
Human Site: T264 Identified Species: 41.11
UniProt: P09668 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09668 NP_004381 335 37394 T264 Q D F M M Y R T G I Y S S T S
Chimpanzee Pan troglodytes XP_001153217 335 37359 T264 Q D F M M Y R T G I Y S S T S
Rhesus Macaque Macaca mulatta XP_001108862 335 37325 T264 Q D F M I Y K T G I Y S S T S
Dog Lupus familis XP_536212 304 34067 Y236 M M Y R K G I Y S S T S C H K
Cat Felis silvestris
Mouse Mus musculus P49935 333 37166 S262 E D F L M Y K S G V Y S S K S
Rat Rattus norvegicus P00786 333 37086 S262 E D F M M Y K S G V Y S S N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521690 408 45641 I338 F R F Y Q S G I F Y E P K C S
Chicken Gallus gallus Q90686 334 37200 Y264 S L P S F Q F Y S R G V Y Y D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_997853 330 37478 D259 S D F M H Y K D G I Y T S T E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95029 371 41582 S301 H E S F Q F Y S E G V Y N E P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002326284 358 39334 E287 G S F R L Y K E G V Y T T S T
Maize Zea mays Q10717 360 39181 S290 T G F R L Y K S G V Y T S D H
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWQ9 358 39523 K288 H E F R F Y K K G V F T S N T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.7 79 N.A. 82.6 82.6 N.A. 35 38.2 N.A. 63.5 N.A. 36.3 N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.5 83.2 N.A. 89.8 89.5 N.A. 50 54 N.A. 74.9 N.A. 51.7 N.A. N.A. N.A.
P-Site Identity: 100 100 86.6 6.6 N.A. 60 66.6 N.A. 13.3 0 N.A. 60 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 13.3 N.A. 93.3 93.3 N.A. 13.3 0 N.A. 73.3 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: 47.7 47.2 N.A. 47.7 N.A. N.A.
Protein Similarity: 60 62.7 N.A. 61.1 N.A. N.A.
P-Site Identity: 26.6 33.3 N.A. 26.6 N.A. N.A.
P-Site Similarity: 73.3 66.6 N.A. 66.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 8 0 % C
% Asp: 0 47 0 0 0 0 0 8 0 0 0 0 0 8 8 % D
% Glu: 16 16 0 0 0 0 0 8 8 0 8 0 0 8 8 % E
% Phe: 8 0 77 8 16 8 8 0 8 0 8 0 0 0 0 % F
% Gly: 8 8 0 0 0 8 8 0 70 8 8 0 0 0 0 % G
% His: 16 0 0 0 8 0 0 0 0 0 0 0 0 8 8 % H
% Ile: 0 0 0 0 8 0 8 8 0 31 0 0 0 0 0 % I
% Lys: 0 0 0 0 8 0 54 8 0 0 0 0 8 8 8 % K
% Leu: 0 8 0 8 16 0 0 0 0 0 0 0 0 0 0 % L
% Met: 8 8 0 39 31 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 8 16 0 % N
% Pro: 0 0 8 0 0 0 0 0 0 0 0 8 0 0 8 % P
% Gln: 24 0 0 0 16 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 8 0 31 0 0 16 0 0 8 0 0 0 0 0 % R
% Ser: 16 8 8 8 0 8 0 31 16 8 0 47 62 8 47 % S
% Thr: 8 0 0 0 0 0 0 24 0 0 8 31 8 31 16 % T
% Val: 0 0 0 0 0 0 0 0 0 39 8 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 8 0 70 8 16 0 8 62 8 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _