KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
20.61
Human Site:
T48
Identified Species:
37.78
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
T48
K
H
R
K
T
Y
S
T
E
E
Y
H
H
R
L
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
T48
K
H
R
K
T
Y
S
T
E
E
Y
H
H
R
L
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
T48
K
H
H
K
T
Y
S
T
E
E
Y
H
H
R
M
Dog
Lupus familis
XP_536212
304
34067
I33
F
V
G
N
W
R
K
I
N
A
H
N
A
G
N
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
S46
Q
H
Q
K
T
Y
S
S
V
E
Y
N
H
R
L
Rat
Rattus norvegicus
P00786
333
37086
S46
Q
H
Q
K
T
Y
S
S
R
E
Y
S
H
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
R118
H
K
A
E
E
G
W
R
R
M
V
W
E
E
N
Chicken
Gallus gallus
Q90686
334
37200
P51
R
Q
G
G
R
N
V
P
E
V
D
L
G
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
I43
Q
Y
N
K
K
Y
E
I
N
E
F
Y
Q
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
E85
F
R
L
K
I
F
N
E
N
K
H
K
I
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
T71
R
H
G
K
R
Y
E
T
E
G
E
M
K
L
R
Maize
Zea mays
Q10717
360
39181
A74
G
K
S
Y
E
S
A
A
E
V
H
K
R
F
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
S72
R
Y
G
K
K
Y
Q
S
V
E
E
M
K
L
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
0
N.A.
66.6
66.6
N.A.
0
6.6
N.A.
33.3
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
13.3
N.A.
93.3
86.6
N.A.
6.6
13.3
N.A.
60
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
33.3
6.6
N.A.
20
N.A.
N.A.
P-Site Similarity:
40
20
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
8
8
0
8
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% D
% Glu:
0
0
0
8
16
0
16
8
47
54
16
0
8
16
8
% E
% Phe:
16
0
0
0
0
8
0
0
0
0
8
0
0
8
0
% F
% Gly:
8
0
31
8
0
8
0
0
0
8
0
0
8
8
0
% G
% His:
8
47
8
0
0
0
0
0
0
0
24
24
39
0
0
% H
% Ile:
0
0
0
0
8
0
0
16
0
0
0
0
8
0
0
% I
% Lys:
24
16
0
70
16
0
8
0
0
8
0
16
16
0
8
% K
% Leu:
0
0
8
0
0
0
0
0
0
0
0
8
0
16
39
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
16
0
0
8
% M
% Asn:
0
0
8
8
0
8
8
0
24
0
0
16
0
0
16
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
24
8
16
0
0
0
8
0
0
0
0
0
8
0
0
% Q
% Arg:
24
8
16
0
16
8
0
8
16
0
0
0
8
47
24
% R
% Ser:
0
0
8
0
0
8
39
24
0
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
39
0
0
31
0
0
0
0
0
0
0
% T
% Val:
0
8
0
0
0
0
8
0
16
16
8
0
0
0
0
% V
% Trp:
0
0
0
0
8
0
8
0
0
0
0
8
0
0
0
% W
% Tyr:
0
16
0
8
0
62
0
0
0
0
39
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _