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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSH All Species: 11.21
Human Site: T57 Identified Species: 20.56
UniProt: P09668 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09668 NP_004381 335 37394 T57 E Y H H R L Q T F A S N W R K
Chimpanzee Pan troglodytes XP_001153217 335 37359 T57 E Y H H R L Q T F A S N W R K
Rhesus Macaque Macaca mulatta XP_001108862 335 37325 T57 E Y H H R M Q T F A S N W R K
Dog Lupus familis XP_536212 304 34067 T42 A H N A G N H T F K M G L N Q
Cat Felis silvestris
Mouse Mus musculus P49935 333 37166 M55 E Y N H R L Q M F A N N W R K
Rat Rattus norvegicus P00786 333 37086 V55 E Y S H R L Q V F A N N W R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521690 408 45641 K127 M V W E E N L K V I E L H N L
Chicken Gallus gallus Q90686 334 37200 E60 V D L G E E P E V H R C P Q R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_997853 330 37478 I52 E F Y Q R L Q I F L E N K K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95029 371 41582 N94 K H K I A K H N Q R F A E G K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002326284 358 39334 A80 G E M K L R F A I F S E S L D
Maize Zea mays Q10717 360 39181 F83 V H K R F R I F S E S L Q L V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWQ9 358 39523 S81 E E M K L R F S V F K E N L D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.7 79 N.A. 82.6 82.6 N.A. 35 38.2 N.A. 63.5 N.A. 36.3 N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.5 83.2 N.A. 89.8 89.5 N.A. 50 54 N.A. 74.9 N.A. 51.7 N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 13.3 N.A. 80 80 N.A. 0 0 N.A. 40 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 33.3 N.A. 93.3 86.6 N.A. 0 13.3 N.A. 66.6 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: 47.7 47.2 N.A. 47.7 N.A. N.A.
Protein Similarity: 60 62.7 N.A. 61.1 N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: 6.6 13.3 N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 8 0 0 8 0 39 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 16 % D
% Glu: 54 16 0 8 16 8 0 8 0 8 16 16 8 0 0 % E
% Phe: 0 8 0 0 8 0 16 8 54 16 8 0 0 0 0 % F
% Gly: 8 0 0 8 8 0 0 0 0 0 0 8 0 8 0 % G
% His: 0 24 24 39 0 0 16 0 0 8 0 0 8 0 0 % H
% Ile: 0 0 0 8 0 0 8 8 8 8 0 0 0 0 0 % I
% Lys: 8 0 16 16 0 8 0 8 0 8 8 0 8 8 47 % K
% Leu: 0 0 8 0 16 39 8 0 0 8 0 16 8 24 8 % L
% Met: 8 0 16 0 0 8 0 8 0 0 8 0 0 0 0 % M
% Asn: 0 0 16 0 0 16 0 8 0 0 16 47 8 16 0 % N
% Pro: 0 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % P
% Gln: 0 0 0 8 0 0 47 0 8 0 0 0 8 8 8 % Q
% Arg: 0 0 0 8 47 24 0 0 0 8 8 0 0 39 16 % R
% Ser: 0 0 8 0 0 0 0 8 8 0 39 0 8 0 0 % S
% Thr: 0 0 0 0 0 0 0 31 0 0 0 0 0 0 0 % T
% Val: 16 8 0 0 0 0 0 8 24 0 0 0 0 0 8 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 39 0 0 % W
% Tyr: 0 39 8 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _