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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
11.21
Human Site:
T57
Identified Species:
20.56
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
T57
E
Y
H
H
R
L
Q
T
F
A
S
N
W
R
K
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
T57
E
Y
H
H
R
L
Q
T
F
A
S
N
W
R
K
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
T57
E
Y
H
H
R
M
Q
T
F
A
S
N
W
R
K
Dog
Lupus familis
XP_536212
304
34067
T42
A
H
N
A
G
N
H
T
F
K
M
G
L
N
Q
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
M55
E
Y
N
H
R
L
Q
M
F
A
N
N
W
R
K
Rat
Rattus norvegicus
P00786
333
37086
V55
E
Y
S
H
R
L
Q
V
F
A
N
N
W
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
K127
M
V
W
E
E
N
L
K
V
I
E
L
H
N
L
Chicken
Gallus gallus
Q90686
334
37200
E60
V
D
L
G
E
E
P
E
V
H
R
C
P
Q
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
I52
E
F
Y
Q
R
L
Q
I
F
L
E
N
K
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
N94
K
H
K
I
A
K
H
N
Q
R
F
A
E
G
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
A80
G
E
M
K
L
R
F
A
I
F
S
E
S
L
D
Maize
Zea mays
Q10717
360
39181
F83
V
H
K
R
F
R
I
F
S
E
S
L
Q
L
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
S81
E
E
M
K
L
R
F
S
V
F
K
E
N
L
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
13.3
N.A.
80
80
N.A.
0
0
N.A.
40
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
33.3
N.A.
93.3
86.6
N.A.
0
13.3
N.A.
66.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
6.6
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
6.6
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
8
0
0
8
0
39
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
16
% D
% Glu:
54
16
0
8
16
8
0
8
0
8
16
16
8
0
0
% E
% Phe:
0
8
0
0
8
0
16
8
54
16
8
0
0
0
0
% F
% Gly:
8
0
0
8
8
0
0
0
0
0
0
8
0
8
0
% G
% His:
0
24
24
39
0
0
16
0
0
8
0
0
8
0
0
% H
% Ile:
0
0
0
8
0
0
8
8
8
8
0
0
0
0
0
% I
% Lys:
8
0
16
16
0
8
0
8
0
8
8
0
8
8
47
% K
% Leu:
0
0
8
0
16
39
8
0
0
8
0
16
8
24
8
% L
% Met:
8
0
16
0
0
8
0
8
0
0
8
0
0
0
0
% M
% Asn:
0
0
16
0
0
16
0
8
0
0
16
47
8
16
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
8
0
0
47
0
8
0
0
0
8
8
8
% Q
% Arg:
0
0
0
8
47
24
0
0
0
8
8
0
0
39
16
% R
% Ser:
0
0
8
0
0
0
0
8
8
0
39
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
31
0
0
0
0
0
0
0
% T
% Val:
16
8
0
0
0
0
0
8
24
0
0
0
0
0
8
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
39
0
0
% W
% Tyr:
0
39
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _