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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
20.91
Human Site:
Y109
Identified Species:
38.33
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
Y109
C
S
A
T
K
S
N
Y
L
R
G
T
G
P
Y
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
Y109
C
S
A
T
K
S
N
Y
L
R
G
T
G
P
Y
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
Y109
C
S
A
T
K
S
N
Y
L
R
G
T
G
P
Y
Dog
Lupus familis
XP_536212
304
34067
G94
F
V
D
W
R
K
K
G
K
F
V
S
P
V
K
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
Y107
C
S
A
T
K
S
N
Y
L
R
G
T
G
P
Y
Rat
Rattus norvegicus
P00786
333
37086
Y107
C
S
A
T
K
S
N
Y
L
R
G
T
G
P
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
F179
N
R
I
N
G
S
A
F
L
E
V
N
Y
V
Q
Chicken
Gallus gallus
Q90686
334
37200
Y112
P
R
P
N
G
T
L
Y
V
P
D
W
S
S
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
H104
C
S
A
T
R
G
N
H
V
S
S
N
G
L
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
F146
E
S
F
K
G
V
T
F
I
S
P
A
H
V
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
N132
C
S
A
T
T
R
G
N
H
K
L
T
N
A
L
Maize
Zea mays
Q10717
360
39181
R135
A
T
L
T
G
N
H
R
M
R
A
A
A
V
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
S133
C
S
A
T
L
K
G
S
H
K
I
T
E
A
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
100
100
N.A.
13.3
6.6
N.A.
46.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
20
20
N.A.
66.6
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
33.3
13.3
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
40
40
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
62
0
0
0
8
0
0
0
8
16
8
16
8
% A
% Cys:
62
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% E
% Phe:
8
0
8
0
0
0
0
16
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
31
8
16
8
0
0
39
0
47
0
0
% G
% His:
0
0
0
0
0
0
8
8
16
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
8
0
8
0
0
0
0
% I
% Lys:
0
0
0
8
39
16
8
0
8
16
0
0
0
0
8
% K
% Leu:
0
0
8
0
8
0
8
0
47
0
8
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
8
0
0
16
0
8
47
8
0
0
0
16
8
0
0
% N
% Pro:
8
0
8
0
0
0
0
0
0
8
8
0
8
39
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
16
0
0
16
8
0
8
0
47
0
0
0
0
8
% R
% Ser:
0
70
0
0
0
47
0
8
0
16
8
8
8
8
0
% S
% Thr:
0
8
0
70
8
8
8
0
0
0
0
54
0
0
16
% T
% Val:
0
8
0
0
0
8
0
0
16
0
16
0
0
31
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
0
8
0
47
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _