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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
28.48
Human Site:
Y195
Identified Species:
52.22
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
Y195
Q
A
F
E
Y
I
L
Y
N
K
G
I
M
G
E
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
Y195
Q
A
F
E
Y
I
L
Y
N
K
G
I
M
G
E
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
Y195
Q
A
F
E
Y
I
L
Y
N
K
G
I
M
G
E
Dog
Lupus familis
XP_536212
304
34067
E171
Y
N
K
G
I
M
G
E
D
S
Y
P
Y
K
G
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
Y193
Q
A
F
E
Y
I
L
Y
N
K
G
I
M
E
E
Rat
Rattus norvegicus
P00786
333
37086
Y193
Q
A
F
E
Y
I
L
Y
N
K
G
I
M
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
E265
F
A
F
Q
Y
I
L
E
N
R
G
I
D
S
E
Chicken
Gallus gallus
Q90686
334
37200
L196
N
A
F
E
Y
V
R
L
N
R
G
I
D
S
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
Y190
H
A
F
E
Y
I
M
Y
N
K
G
L
M
T
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
D232
N
A
F
R
Y
I
K
D
N
G
G
I
D
T
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
F218
Q
A
F
E
Y
I
K
F
N
G
G
L
D
T
E
Maize
Zea mays
Q10717
360
39181
Y221
Q
A
F
E
Y
I
K
Y
N
G
G
L
D
T
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
Y219
Q
A
F
E
Y
I
K
Y
N
G
G
L
D
T
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
93.3
100
N.A.
60
53.3
N.A.
73.3
N.A.
53.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
93.3
100
N.A.
73.3
66.6
N.A.
86.6
N.A.
53.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
60
66.6
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
73.3
73.3
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
93
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
8
0
0
0
47
0
0
% D
% Glu:
0
0
0
77
0
0
0
16
0
0
0
0
0
8
93
% E
% Phe:
8
0
93
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
8
0
0
31
93
0
0
31
8
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
85
0
0
0
0
0
62
0
0
0
% I
% Lys:
0
0
8
0
0
0
31
0
0
47
0
0
0
8
0
% K
% Leu:
0
0
0
0
0
0
47
8
0
0
0
31
0
0
0
% L
% Met:
0
0
0
0
0
8
8
0
0
0
0
0
47
0
0
% M
% Asn:
16
8
0
0
0
0
0
0
93
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
62
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
8
0
0
16
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
8
0
0
0
16
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
39
0
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
93
0
0
62
0
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _