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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSH All Species: 35.45
Human Site: Y207 Identified Species: 65
UniProt: P09668 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09668 NP_004381 335 37394 Y207 M G E D T Y P Y Q G K D G Y C
Chimpanzee Pan troglodytes XP_001153217 335 37359 Y207 M G E D T Y P Y Q G K D G Y C
Rhesus Macaque Macaca mulatta XP_001108862 335 37325 Y207 M G E D T Y P Y Q G K D G D C
Dog Lupus familis XP_536212 304 34067 C183 Y K G Q D G D C K Y Q P S K A
Cat Felis silvestris
Mouse Mus musculus P49935 333 37166 Y205 M E E D S Y P Y I G K D S S C
Rat Rattus norvegicus P00786 333 37086 Y205 M G E D S Y P Y I G K N G Q C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521690 408 45641 Y277 D S E D C Y P Y T A K D T A Q
Chicken Gallus gallus Q90686 334 37200 Y208 D S E D A Y P Y I G Q D E S C
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_997853 330 37478 Y202 M T E D D Y P Y Q A K G G Q C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95029 371 41582 Y244 D T E K S Y P Y E A I D D S C
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002326284 358 39334 Y230 D T E E A Y P Y T G K D D A C
Maize Zea mays Q10717 360 39181 Y233 D T E E S Y P Y Q G V N G I C
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RWQ9 358 39523 Y231 D T E E A Y P Y T G K D G G C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 96.7 79 N.A. 82.6 82.6 N.A. 35 38.2 N.A. 63.5 N.A. 36.3 N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.5 83.2 N.A. 89.8 89.5 N.A. 50 54 N.A. 74.9 N.A. 51.7 N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 0 N.A. 66.6 73.3 N.A. 46.6 53.3 N.A. 66.6 N.A. 40 N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 13.3 N.A. 73.3 86.6 N.A. 46.6 60 N.A. 66.6 N.A. 53.3 N.A. N.A. N.A.
Percent
Protein Identity: 47.7 47.2 N.A. 47.7 N.A. N.A.
Protein Similarity: 60 62.7 N.A. 61.1 N.A. N.A.
P-Site Identity: 53.3 53.3 N.A. 60 N.A. N.A.
P-Site Similarity: 60 73.3 N.A. 66.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 24 0 0 0 0 24 0 0 0 16 8 % A
% Cys: 0 0 0 0 8 0 0 8 0 0 0 0 0 0 85 % C
% Asp: 47 0 0 62 16 0 8 0 0 0 0 70 16 8 0 % D
% Glu: 0 8 93 24 0 0 0 0 8 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 31 8 0 0 8 0 0 0 70 0 8 54 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 24 0 8 0 0 8 0 % I
% Lys: 0 8 0 8 0 0 0 0 8 0 70 0 0 8 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 47 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 16 0 0 0 % N
% Pro: 0 0 0 0 0 0 93 0 0 0 0 8 0 0 0 % P
% Gln: 0 0 0 8 0 0 0 0 39 0 16 0 0 16 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 16 0 0 31 0 0 0 0 0 0 0 16 24 0 % S
% Thr: 0 39 0 0 24 0 0 0 24 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 93 0 93 0 8 0 0 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _