KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
12.42
Human Site:
Y234
Identified Species:
22.78
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
Y234
D
V
A
N
I
T
I
Y
D
E
E
A
M
V
E
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
Y234
D
V
A
N
I
T
I
Y
D
E
E
A
M
V
E
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
Y234
D
V
A
N
I
T
I
Y
D
E
E
A
M
V
E
Dog
Lupus familis
XP_536212
304
34067
Q206
N
I
T
I
N
D
E
Q
A
M
V
E
A
V
A
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
N232
N
V
V
N
I
T
L
N
D
E
A
A
M
V
E
Rat
Rattus norvegicus
P00786
333
37086
N232
N
V
V
N
I
T
L
N
D
E
A
A
M
V
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
E308
D
I
P
P
H
S
E
E
A
L
M
K
A
V
A
Chicken
Gallus gallus
Q90686
334
37200
E234
R
G
Y
R
E
I
P
E
D
N
E
K
A
L
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
Y229
E
V
V
N
I
T
K
Y
D
E
M
G
M
V
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
G271
G
F
T
D
I
P
Q
G
D
E
K
K
M
A
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
G257
E
S
V
N
I
T
L
G
A
E
D
E
L
K
H
Maize
Zea mays
Q10717
360
39181
G260
D
S
V
N
I
T
L
G
A
E
D
E
L
K
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
G258
D
S
V
N
I
T
L
G
A
E
D
E
L
K
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
66.6
66.6
N.A.
13.3
13.3
N.A.
60
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
80
80
N.A.
26.6
26.6
N.A.
73.3
N.A.
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
26.6
33.3
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
53.3
60
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
24
0
0
0
0
0
39
0
16
39
24
8
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
0
0
8
0
8
0
0
62
0
24
0
0
0
16
% D
% Glu:
16
0
0
0
8
0
16
16
0
77
31
31
0
0
47
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
8
0
0
0
0
0
31
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
16
% H
% Ile:
0
16
0
8
77
8
24
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
8
24
0
24
8
% K
% Leu:
0
0
0
0
0
0
39
0
0
8
0
0
24
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
8
16
0
54
0
0
% M
% Asn:
24
0
0
70
8
0
0
16
0
8
0
0
0
0
0
% N
% Pro:
0
0
8
8
0
8
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
24
0
0
0
8
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
16
0
0
70
0
0
0
0
0
0
0
0
0
% T
% Val:
0
47
47
0
0
0
0
0
0
0
8
0
0
62
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
31
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _