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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSH
All Species:
34.55
Human Site:
Y312
Identified Species:
63.33
UniProt:
P09668
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09668
NP_004381
335
37394
Y312
P
Q
W
G
M
N
G
Y
F
L
I
E
R
G
K
Chimpanzee
Pan troglodytes
XP_001153217
335
37359
Y312
P
Q
W
G
M
N
G
Y
F
L
I
E
R
G
K
Rhesus Macaque
Macaca mulatta
XP_001108862
335
37325
Y312
P
Q
W
G
M
N
G
Y
F
L
I
E
R
G
K
Dog
Lupus familis
XP_536212
304
34067
M284
G
M
N
G
Y
F
L
M
E
R
G
K
N
M
C
Cat
Felis silvestris
Mouse
Mus musculus
P49935
333
37166
Y310
S
Q
W
G
E
N
G
Y
F
L
I
E
R
G
K
Rat
Rattus norvegicus
P00786
333
37086
Y310
S
N
W
G
N
N
G
Y
F
L
I
E
R
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521690
408
45641
Y386
K
Q
W
G
D
H
G
Y
F
Y
L
S
K
D
R
Chicken
Gallus gallus
Q90686
334
37200
Y312
T
E
W
G
N
K
G
Y
V
L
L
A
R
N
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_997853
330
37478
Y307
T
N
W
G
I
K
G
Y
F
Y
I
E
R
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95029
371
41582
F349
T
T
W
G
D
K
G
F
I
K
M
L
R
N
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326284
358
39334
Y335
E
D
W
G
D
N
G
Y
F
K
M
E
M
G
K
Maize
Zea mays
Q10717
360
39181
Y338
A
D
W
G
D
E
G
Y
F
K
M
E
M
G
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RWQ9
358
39523
Y336
G
E
W
G
D
N
G
Y
F
K
M
E
M
G
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.7
79
N.A.
82.6
82.6
N.A.
35
38.2
N.A.
63.5
N.A.
36.3
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
98.5
83.2
N.A.
89.8
89.5
N.A.
50
54
N.A.
74.9
N.A.
51.7
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
86.6
80
N.A.
40
40
N.A.
66.6
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
86.6
80
N.A.
66.6
53.3
N.A.
73.3
N.A.
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
47.7
47.2
N.A.
47.7
N.A.
N.A.
Protein Similarity:
60
62.7
N.A.
61.1
N.A.
N.A.
P-Site Identity:
60
53.3
N.A.
60
N.A.
N.A.
P-Site Similarity:
66.6
60
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
16
0
0
39
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
8
16
0
0
8
8
0
0
8
0
0
70
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
8
77
0
0
0
0
0
0
% F
% Gly:
16
0
0
100
0
0
93
0
0
0
8
0
0
70
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
8
0
47
0
0
0
0
% I
% Lys:
8
0
0
0
0
24
0
0
0
31
0
8
8
0
77
% K
% Leu:
0
0
0
0
0
0
8
0
0
47
16
8
0
0
0
% L
% Met:
0
8
0
0
24
0
0
8
0
0
31
0
24
8
8
% M
% Asn:
0
16
8
0
16
54
0
0
0
0
0
0
8
16
0
% N
% Pro:
24
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
39
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
62
0
8
% R
% Ser:
16
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% S
% Thr:
24
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
93
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
85
0
16
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _