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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALPI All Species: 7.58
Human Site: S431 Identified Species: 13.89
UniProt: P09923 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09923 NP_001622.2 528 56812 S431 V R P D V N E S E S G S P D Y
Chimpanzee Pan troglodytes XP_001142681 961 103936 S864 V R P D V N E S E S G D P D Y
Rhesus Macaque Macaca mulatta XP_001109717 652 71041 M561 G E R E N V S M V D Y A H N N
Dog Lupus familis XP_534605 554 59751 A434 P R P N F S D A E S R D P A Y
Cat Felis silvestris
Mouse Mus musculus P24823 529 57193 E430 A R A D V T E E E S S N P T Y
Rat Rattus norvegicus P15693 540 58384 A432 N R P N V T D A E S G D V N Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q92058 519 56742 A432 G E R E N V S A V D F A H A N
Frog Xenopus laevis NP_001091135 530 58155 N433 G R P N V N S N L S E D V N Y
Zebra Danio Brachydanio rerio NP_001020359 521 56944 S431 T R P D V N E S V S G R D D Y
Tiger Blowfish Takifugu rubipres NP_001027823 527 57490 A436 G G R E N V S A I D Y Q E N N
Fruit Fly Dros. melanogaster Q24238 596 65244 N470 A N D S R P Q N S S N M W M P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001130844 524 57641 M433 G E R E N V S M V D Y A H N N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P11491 566 62986 K438 I K H E I L E K D L G I Y D Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 54.1 47.7 76.3 N.A. 75.8 76.1 N.A. N.A. 57.3 63.9 59.4 56.2 41.1 N.A. N.A. N.A.
Protein Similarity: 100 54.5 59.5 83 N.A. 85.6 85.5 N.A. N.A. 71.5 76.7 73.1 71.5 54 N.A. N.A. N.A.
P-Site Identity: 100 93.3 0 40 N.A. 53.3 46.6 N.A. N.A. 0 40 73.3 0 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 93.3 20 66.6 N.A. 60 73.3 N.A. N.A. 20 60 73.3 20 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. 57 N.A. N.A. 25.6 N.A.
Protein Similarity: N.A. 73.1 N.A. N.A. 41.3 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. 20 N.A. N.A. 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 8 0 0 0 0 31 0 0 0 24 0 16 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 31 0 0 16 0 8 31 0 31 8 31 0 % D
% Glu: 0 24 0 39 0 0 39 8 39 0 8 0 8 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 39 8 0 0 0 0 0 0 0 0 39 0 0 0 0 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 0 24 0 0 % H
% Ile: 8 0 0 0 8 0 0 0 8 0 0 8 0 0 0 % I
% Lys: 0 8 0 0 0 0 0 8 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 8 0 0 8 8 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 16 0 0 0 8 0 8 0 % M
% Asn: 8 8 0 24 31 31 0 16 0 0 8 8 0 39 31 % N
% Pro: 8 0 47 0 0 8 0 0 0 0 0 0 31 0 8 % P
% Gln: 0 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % Q
% Arg: 0 54 31 0 8 0 0 0 0 0 8 8 0 0 0 % R
% Ser: 0 0 0 8 0 8 39 24 8 62 8 8 0 0 0 % S
% Thr: 8 0 0 0 0 16 0 0 0 0 0 0 0 8 0 % T
% Val: 16 0 0 0 47 31 0 0 31 0 0 0 16 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 24 0 8 0 62 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _