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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FURIN All Species: 31.21
Human Site: S679 Identified Species: 57.22
UniProt: P09958 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P09958 NP_002560.1 794 86678 S679 E Q T C S R Q S Q S S R E S P
Chimpanzee Pan troglodytes XP_510596 794 86649 S679 E Q T C S R Q S Q S S R E S P
Rhesus Macaque Macaca mulatta XP_001094068 794 86687 S679 E Q T C S R Q S Q S S R E S P
Dog Lupus familis XP_850069 801 87503 S687 E Q T C S R Q S Q S S R E S P
Cat Felis silvestris
Mouse Mus musculus P23188 793 86786 S679 E Q T C S R Q S Q S S R E S R
Rat Rattus norvegicus P23377 793 86635 S679 E Q T C S R Q S Q S S R E S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_990046 789 86613 T682 D L S C S H Q T Q S S R A S P
Frog Xenopus laevis P29119 783 86425 T677 D Y S C T H Q T Q R S R E S P
Zebra Danio Brachydanio rerio NP_001038574 823 89738 V686 S C L H Q N Q V Q R K S P S I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26016 1269 138609 S1011 K E S T T T S S N S R I P K L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P51559 943 103128 P773 K C V E S C P P G L V A D Y E
Sea Urchin Strong. purpuratus XP_780373 746 81468 L643 C V H C S P D L E K D G S Y C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 R704 F F M K S R R R I R R S R A E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.8 93.5 N.A. 93.6 93.6 N.A. N.A. 79.8 70.2 63.7 N.A. 32.5 N.A. 37.4 48.9
Protein Similarity: 100 99.7 99.2 95 N.A. 95.7 95.2 N.A. N.A. 86.4 80.8 75 N.A. 42.7 N.A. 50.2 61.2
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 60 53.3 20 N.A. 13.3 N.A. 6.6 13.3
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 80 80 20 N.A. 40 N.A. 20 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 8 8 8 0 % A
% Cys: 8 16 0 70 0 8 0 0 0 0 0 0 0 0 8 % C
% Asp: 16 0 0 0 0 0 8 0 0 0 8 0 8 0 0 % D
% Glu: 47 8 0 8 0 0 0 0 8 0 0 0 54 0 16 % E
% Phe: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 0 % G
% His: 0 0 8 8 0 16 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 8 % I
% Lys: 16 0 0 8 0 0 0 0 0 8 8 0 0 8 0 % K
% Leu: 0 8 8 0 0 0 0 8 0 8 0 0 0 0 8 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 8 8 8 0 0 0 0 16 0 47 % P
% Gln: 0 47 0 0 8 0 70 0 70 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 54 8 8 0 24 16 62 8 0 16 % R
% Ser: 8 0 24 0 77 0 8 54 0 62 62 16 8 70 0 % S
% Thr: 0 0 47 8 16 8 0 16 0 0 0 0 0 0 0 % T
% Val: 0 8 8 0 0 0 0 8 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _