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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE2
All Species:
21.21
Human Site:
S386
Identified Species:
38.89
UniProt:
P0C1S8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P0C1S8
NP_001099028.1
567
62925
S386
G
D
L
G
H
A
T
S
I
N
K
P
K
V
E
Chimpanzee
Pan troglodytes
XP_519504
455
50573
E281
S
I
N
K
P
K
V
E
E
G
D
S
R
F
L
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
S387
G
D
L
G
H
A
T
S
I
N
E
P
K
V
E
Dog
Lupus familis
XP_532748
515
57465
L341
H
N
S
G
M
V
H
L
D
I
K
P
S
N
I
Cat
Felis silvestris
Mouse
Mus musculus
Q66JT0
555
62324
S381
G
D
L
G
H
A
T
S
I
S
K
P
K
V
E
Rat
Rattus norvegicus
Q63802
646
71478
P472
H
V
T
R
I
S
S
P
Q
V
E
E
G
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520344
429
47032
V255
T
S
I
R
N
P
Q
V
E
E
G
D
S
R
F
Chicken
Gallus gallus
NP_001026352
641
70947
S467
L
G
H
V
T
R
V
S
S
P
Q
V
E
E
G
Frog
Xenopus laevis
P47817
555
61670
S380
G
D
L
G
H
V
T
S
I
L
N
P
Q
V
E
Zebra Danio
Brachydanio rerio
NP_001032299
527
59094
V353
K
I
G
D
L
G
H
V
T
S
I
S
S
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
S418
G
D
L
G
H
V
T
S
V
K
E
P
Y
V
E
Honey Bee
Apis mellifera
XP_624069
589
66032
S408
G
D
L
G
H
V
T
S
V
N
N
P
Q
V
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
M406
H
S
E
G
L
V
H
M
D
I
K
P
G
N
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.7
94.3
71.9
N.A.
66.8
43
N.A.
47.7
42.1
52.9
43.5
N.A.
33.5
36.1
N.A.
39.2
Protein Similarity:
100
78.1
95.9
77.7
N.A.
76.5
56.8
N.A.
57.1
57.8
64.9
58.9
N.A.
50.7
52.6
N.A.
55.2
P-Site Identity:
100
0
93.3
20
N.A.
93.3
0
N.A.
0
6.6
73.3
0
N.A.
66.6
73.3
N.A.
20
P-Site Similarity:
100
6.6
100
26.6
N.A.
100
20
N.A.
13.3
20
80
13.3
N.A.
80
86.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
24
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
47
0
8
0
0
0
0
16
0
8
8
0
8
0
% D
% Glu:
0
0
8
0
0
0
0
8
16
8
24
8
8
8
47
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% F
% Gly:
47
8
8
62
0
8
0
0
0
8
8
0
16
0
8
% G
% His:
24
0
8
0
47
0
24
0
0
0
0
0
0
0
0
% H
% Ile:
0
16
8
0
8
0
0
0
31
16
8
0
0
0
16
% I
% Lys:
8
0
0
8
0
8
0
0
0
8
31
0
24
0
0
% K
% Leu:
8
0
47
0
16
0
0
8
0
8
0
0
0
0
8
% L
% Met:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
8
0
0
0
0
24
16
0
0
16
0
% N
% Pro:
0
0
0
0
8
8
0
8
0
8
0
62
0
8
0
% P
% Gln:
0
0
0
0
0
0
8
0
8
0
8
0
16
0
8
% Q
% Arg:
0
0
0
16
0
8
0
0
0
0
0
0
8
8
0
% R
% Ser:
8
16
8
0
0
8
8
54
8
16
0
16
24
0
8
% S
% Thr:
8
0
8
0
8
0
47
0
8
0
0
0
0
0
0
% T
% Val:
0
8
0
8
0
39
16
16
16
8
0
8
0
47
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _