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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE2
All Species:
5.15
Human Site:
S461
Identified Species:
9.44
UniProt:
P0C1S8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P0C1S8
NP_001099028.1
567
62925
S461
E
L
S
E
S
F
S
S
L
L
K
N
M
I
Q
Chimpanzee
Pan troglodytes
XP_519504
455
50573
L350
L
S
E
S
F
S
S
L
L
K
N
M
I
Q
P
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
S462
E
L
S
E
S
F
S
S
L
L
K
N
M
I
H
Dog
Lupus familis
XP_532748
515
57465
E410
L
A
N
E
I
L
Q
E
D
Y
Q
H
L
P
K
Cat
Felis silvestris
Mouse
Mus musculus
Q66JT0
555
62324
L450
F
P
E
I
S
Q
E
L
S
D
D
F
Y
G
L
Rat
Rattus norvegicus
Q63802
646
71478
L541
P
Q
V
L
S
Q
E
L
T
E
L
L
K
V
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520344
429
47032
N324
R
L
S
E
D
F
Y
N
L
L
K
L
T
I
D
Chicken
Gallus gallus
NP_001026352
641
70947
Q536
R
I
P
Q
V
L
S
Q
E
L
L
D
L
L
K
Frog
Xenopus laevis
P47817
555
61670
T450
P
H
V
P
Q
L
L
T
P
V
F
L
A
L
L
Zebra Danio
Brachydanio rerio
NP_001032299
527
59094
H422
G
E
L
P
N
L
P
H
E
L
P
A
L
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
L493
L
S
R
D
F
N
E
L
I
A
Q
M
M
H
P
Honey Bee
Apis mellifera
XP_624069
589
66032
E482
H
Y
S
R
D
L
N
E
L
L
K
L
M
I
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
A502
L
A
L
T
A
Y
L
A
A
G
G
E
S
L
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.7
94.3
71.9
N.A.
66.8
43
N.A.
47.7
42.1
52.9
43.5
N.A.
33.5
36.1
N.A.
39.2
Protein Similarity:
100
78.1
95.9
77.7
N.A.
76.5
56.8
N.A.
57.1
57.8
64.9
58.9
N.A.
50.7
52.6
N.A.
55.2
P-Site Identity:
100
13.3
93.3
6.6
N.A.
6.6
6.6
N.A.
53.3
13.3
0
6.6
N.A.
6.6
40
N.A.
0
P-Site Similarity:
100
20
93.3
40
N.A.
6.6
13.3
N.A.
60
53.3
20
26.6
N.A.
26.6
46.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
8
0
0
8
8
8
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
16
0
0
0
8
8
8
8
0
0
8
% D
% Glu:
16
8
16
31
0
0
24
16
16
8
0
8
0
0
0
% E
% Phe:
8
0
0
0
16
24
0
0
0
0
8
8
0
8
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
8
8
0
0
8
0
% G
% His:
8
8
0
0
0
0
0
8
0
0
0
8
0
8
16
% H
% Ile:
0
8
0
8
8
0
0
0
8
0
0
0
8
31
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
31
0
8
0
24
% K
% Leu:
31
24
16
8
0
39
16
31
39
47
16
31
24
24
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
16
31
0
8
% M
% Asn:
0
0
8
0
8
8
8
8
0
0
8
16
0
0
0
% N
% Pro:
16
8
8
16
0
0
8
0
8
0
8
0
0
8
24
% P
% Gln:
0
8
0
8
8
16
8
8
0
0
16
0
0
8
8
% Q
% Arg:
16
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
16
31
8
31
8
31
16
8
0
0
0
8
0
0
% S
% Thr:
0
0
0
8
0
0
0
8
8
0
0
0
8
0
0
% T
% Val:
0
0
16
0
8
0
0
0
0
8
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
8
0
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _