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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE2
All Species:
9.7
Human Site:
Y227
Identified Species:
17.78
UniProt:
P0C1S8
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P0C1S8
NP_001099028.1
567
62925
Y227
V
G
E
F
G
T
V
Y
K
C
I
K
R
L
D
Chimpanzee
Pan troglodytes
XP_519504
455
50573
C124
C
I
K
R
L
D
G
C
V
Y
A
I
K
R
S
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
Y228
V
G
E
F
G
T
V
Y
K
C
I
K
R
L
D
Dog
Lupus familis
XP_532748
515
57465
A184
T
R
G
D
L
E
E
A
D
P
G
E
G
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q66JT0
555
62324
V222
G
V
G
E
F
G
T
V
Y
K
C
I
K
R
L
Rat
Rattus norvegicus
Q63802
646
71478
F313
S
G
E
F
G
S
V
F
K
C
V
K
R
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520344
429
47032
G98
K
C
I
K
R
L
D
G
C
I
Y
A
I
K
R
Chicken
Gallus gallus
NP_001026352
641
70947
F310
S
G
E
F
G
S
V
F
K
C
V
K
R
L
D
Frog
Xenopus laevis
P47817
555
61670
S223
I
G
A
G
E
F
G
S
V
F
K
C
V
K
R
Zebra Danio
Brachydanio rerio
NP_001032299
527
59094
S196
I
G
V
G
E
F
G
S
V
Y
R
C
V
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
F254
V
G
E
F
G
V
V
F
Q
C
V
N
R
L
D
Honey Bee
Apis mellifera
XP_624069
589
66032
Y248
T
G
E
F
G
S
V
Y
K
C
I
N
R
L
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
R238
N
A
T
K
K
R
L
R
Q
E
R
S
I
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
77.7
94.3
71.9
N.A.
66.8
43
N.A.
47.7
42.1
52.9
43.5
N.A.
33.5
36.1
N.A.
39.2
Protein Similarity:
100
78.1
95.9
77.7
N.A.
76.5
56.8
N.A.
57.1
57.8
64.9
58.9
N.A.
50.7
52.6
N.A.
55.2
P-Site Identity:
100
0
100
0
N.A.
0
73.3
N.A.
0
73.3
6.6
6.6
N.A.
66.6
80
N.A.
13.3
P-Site Similarity:
100
13.3
100
6.6
N.A.
6.6
93.3
N.A.
0
93.3
13.3
13.3
N.A.
86.6
86.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
0
0
8
0
0
8
8
0
0
0
% A
% Cys:
8
8
0
0
0
0
0
8
8
47
8
16
0
0
0
% C
% Asp:
0
0
0
8
0
8
8
0
8
0
0
0
0
0
54
% D
% Glu:
0
0
47
8
16
8
8
0
0
8
0
8
0
0
0
% E
% Phe:
0
0
0
47
8
16
0
24
0
8
0
0
0
0
0
% F
% Gly:
8
62
16
16
47
8
24
8
0
0
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
16
8
8
0
0
0
0
0
0
8
24
16
16
0
0
% I
% Lys:
8
0
8
16
8
0
0
0
39
8
8
31
16
31
0
% K
% Leu:
0
0
0
0
16
8
8
0
0
0
0
0
0
54
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% Q
% Arg:
0
8
0
8
8
8
0
8
0
0
16
0
47
16
24
% R
% Ser:
16
0
0
0
0
24
0
16
0
0
0
8
0
0
8
% S
% Thr:
16
0
8
0
0
16
8
0
0
0
0
0
0
0
0
% T
% Val:
24
8
8
0
0
8
47
8
24
0
24
0
16
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
24
8
16
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _