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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GLI3
All Species:
24.24
Human Site:
S338
Identified Species:
59.26
UniProt:
P10071
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10071
NP_000159.3
1580
169863
S338
S
G
S
Y
G
H
L
S
A
S
A
I
S
P
A
Chimpanzee
Pan troglodytes
Q5IS56
1580
169881
S338
S
G
S
Y
G
H
L
S
A
S
A
I
S
P
A
Rhesus Macaque
Macaca mulatta
XP_001098108
1580
169984
S338
S
G
S
Y
G
H
L
S
A
S
A
I
S
P
A
Dog
Lupus familis
XP_540363
1589
168926
S337
S
G
S
Y
G
H
L
S
A
S
A
I
S
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61602
1583
171637
S338
S
G
S
Y
G
H
L
S
A
S
A
I
S
P
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506723
1591
170747
S338
S
G
S
Y
G
H
L
S
A
S
A
I
S
P
A
Chicken
Gallus gallus
P55879
663
73088
Frog
Xenopus laevis
Q91660
1569
172575
A341
S
G
S
Y
G
H
L
A
A
S
A
I
S
P
A
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P19538
1397
153262
T310
F
S
I
G
H
M
P
T
S
A
S
L
R
V
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34708
1110
122786
E122
A
L
G
A
S
S
D
E
L
L
Q
P
N
A
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.6
86.4
N.A.
86.4
N.A.
N.A.
79.4
29.1
68.8
N.A.
N.A.
23
N.A.
20.5
N.A.
Protein Similarity:
100
99.8
99
90.1
N.A.
90.9
N.A.
N.A.
86.2
34.8
79.8
N.A.
N.A.
37.7
N.A.
35.1
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
100
0
93.3
N.A.
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
100
0
100
N.A.
N.A.
33.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
10
0
0
0
10
70
10
70
0
0
10
70
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
70
10
10
70
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
70
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
70
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
0
0
70
0
10
10
0
10
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% N
% Pro:
0
0
0
0
0
0
10
0
0
0
0
10
0
70
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% R
% Ser:
70
10
70
0
10
10
0
60
10
70
10
0
70
0
0
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
70
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _