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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSA All Species: 18.48
Human Site: S376 Identified Species: 36.97
UniProt: P10619 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10619 NP_000299.2 480 54466 S376 Q Y R R L Y R S M N S Q Y L K
Chimpanzee Pan troglodytes XP_001159669 495 55859 S391 Q Y R R L Y R S M N S Q Y L K
Rhesus Macaque Macaca mulatta XP_001106032 494 55727 S390 Q Y R R L Y R S M N S Q Y L K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P16675 474 53826 S370 Q Y R R L Y Q S M N S Q Y L K
Rat Rattus norvegicus NP_001011959 456 51197 D355 P E S L P R W D M C N L M V N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026662 471 53136 Q368 S Y K R L Y M Q M N D Q Y L K
Frog Xenopus laevis NP_001088109 470 52915 S367 T Y G R I Y Q S M K D H Y L K
Zebra Danio Brachydanio rerio NP_956844 471 53005 D368 N Y N R L F M D V K K Q Y L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52717 469 53628 T370 T T Y Q K Q Y T D M T P F I K
Sea Urchin Strong. purpuratus XP_798670 470 52291 Y371 A L P Y K T I Y A T M Y D T Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L7B2 497 55814 G397 L S F Y H D A G S M I D F H R
Baker's Yeast Sacchar. cerevisiae P38109 508 57620 K391 L F T G D G S K P F Q Q Y I A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 94.5 N.A. N.A. 86.8 78.3 N.A. N.A. 65.8 61.6 63.1 N.A. N.A. N.A. 39.3 47.2
Protein Similarity: 100 95.1 94.9 N.A. N.A. 92 84.7 N.A. N.A. 77.7 75.8 77 N.A. N.A. N.A. 58.9 65.4
P-Site Identity: 100 100 100 N.A. N.A. 93.3 6.6 N.A. N.A. 66.6 53.3 46.6 N.A. N.A. N.A. 6.6 0
P-Site Similarity: 100 100 100 N.A. N.A. 100 20 N.A. N.A. 73.3 66.6 60 N.A. N.A. N.A. 40 0
Percent
Protein Identity: N.A. N.A. N.A. 37.4 28.5 N.A.
Protein Similarity: N.A. N.A. N.A. 57.7 44.6 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 0 0 9 0 9 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % C
% Asp: 0 0 0 0 9 9 0 17 9 0 17 9 9 0 0 % D
% Glu: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 9 9 0 0 9 0 0 0 9 0 0 17 0 0 % F
% Gly: 0 0 9 9 0 9 0 9 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 9 0 9 0 % H
% Ile: 0 0 0 0 9 0 9 0 0 0 9 0 0 17 0 % I
% Lys: 0 0 9 0 17 0 0 9 0 17 9 0 0 0 67 % K
% Leu: 17 9 0 9 50 0 0 0 0 0 0 9 0 59 0 % L
% Met: 0 0 0 0 0 0 17 0 59 17 9 0 9 0 0 % M
% Asn: 9 0 9 0 0 0 0 0 0 42 9 0 0 0 9 % N
% Pro: 9 0 9 0 9 0 0 0 9 0 0 9 0 0 0 % P
% Gln: 34 0 0 9 0 9 17 9 0 0 9 59 0 0 0 % Q
% Arg: 0 0 34 59 0 9 25 0 0 0 0 0 0 0 9 % R
% Ser: 9 9 9 0 0 0 9 42 9 0 34 0 0 0 0 % S
% Thr: 17 9 9 0 0 9 0 9 0 9 9 0 0 9 0 % T
% Val: 0 0 0 0 0 0 0 0 9 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % W
% Tyr: 0 59 9 17 0 50 9 9 0 0 0 9 67 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _