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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSA All Species: 15.76
Human Site: Y291 Identified Species: 31.52
UniProt: P10619 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10619 NP_000299.2 480 54466 Y291 G V P S H F R Y E K D T V V V
Chimpanzee Pan troglodytes XP_001159669 495 55859 Y306 G V P S H F R Y E K D T V V V
Rhesus Macaque Macaca mulatta XP_001106032 494 55727 Y305 G V P S H F R Y E K D T V V V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P16675 474 53826 Y286 G V P G R H R Y E D T L V V Q
Rat Rattus norvegicus NP_001011959 456 51197 V280 Y A P C A G G V P G R D R S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026662 471 53136 Y280 G V P G S M R Y E G D Y L I T
Frog Xenopus laevis NP_001088109 470 52915 D281 G A P G E V K D N G D H I I V
Zebra Danio Brachydanio rerio NP_956844 471 53005 F280 G V G Q R F G F E N G Q F V I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52717 469 53628 V275 D C D P N P S V N S K R M K H
Sea Urchin Strong. purpuratus XP_798670 470 52291 S288 N G P S S V K S P L L T R Y Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L7B2 497 55814 S305 F D I R S L P S S L L Q L G K
Baker's Yeast Sacchar. cerevisiae P38109 508 57620 D315 I V A T A Y C D S A L L E P Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 94.5 N.A. N.A. 86.8 78.3 N.A. N.A. 65.8 61.6 63.1 N.A. N.A. N.A. 39.3 47.2
Protein Similarity: 100 95.1 94.9 N.A. N.A. 92 84.7 N.A. N.A. 77.7 75.8 77 N.A. N.A. N.A. 58.9 65.4
P-Site Identity: 100 100 100 N.A. N.A. 53.3 6.6 N.A. N.A. 46.6 26.6 33.3 N.A. N.A. N.A. 0 20
P-Site Similarity: 100 100 100 N.A. N.A. 53.3 6.6 N.A. N.A. 60 46.6 46.6 N.A. N.A. N.A. 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 37.4 28.5 N.A.
Protein Similarity: N.A. N.A. N.A. 57.7 44.6 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 9 0 17 0 0 0 0 9 0 0 0 0 0 % A
% Cys: 0 9 0 9 0 0 9 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 9 0 0 0 0 17 0 9 42 9 0 0 0 % D
% Glu: 0 0 0 0 9 0 0 0 50 0 0 0 9 0 9 % E
% Phe: 9 0 0 0 0 34 0 9 0 0 0 0 9 0 0 % F
% Gly: 59 9 9 25 0 9 17 0 0 25 9 0 0 9 0 % G
% His: 0 0 0 0 25 9 0 0 0 0 0 9 0 0 9 % H
% Ile: 9 0 9 0 0 0 0 0 0 0 0 0 9 17 9 % I
% Lys: 0 0 0 0 0 0 17 0 0 25 9 0 0 9 9 % K
% Leu: 0 0 0 0 0 9 0 0 0 17 25 17 17 0 0 % L
% Met: 0 0 0 0 0 9 0 0 0 0 0 0 9 0 0 % M
% Asn: 9 0 0 0 9 0 0 0 17 9 0 0 0 0 0 % N
% Pro: 0 0 67 9 0 9 9 0 17 0 0 0 0 9 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 0 17 0 0 17 % Q
% Arg: 0 0 0 9 17 0 42 0 0 0 9 9 17 0 0 % R
% Ser: 0 0 0 34 25 0 9 17 17 9 0 0 0 9 0 % S
% Thr: 0 0 0 9 0 0 0 0 0 0 9 34 0 0 9 % T
% Val: 0 59 0 0 0 17 0 17 0 0 0 0 34 42 34 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 9 0 42 0 0 0 9 0 9 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _