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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSA
All Species:
19.09
Human Site:
Y374
Identified Species:
38.18
UniProt:
P10619
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10619
NP_000299.2
480
54466
Y374
N
L
Q
Y
R
R
L
Y
R
S
M
N
S
Q
Y
Chimpanzee
Pan troglodytes
XP_001159669
495
55859
Y389
N
L
Q
Y
R
R
L
Y
R
S
M
N
S
Q
Y
Rhesus Macaque
Macaca mulatta
XP_001106032
494
55727
Y388
N
L
Q
Y
R
R
L
Y
R
S
M
N
S
Q
Y
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P16675
474
53826
Y368
N
L
Q
Y
R
R
L
Y
Q
S
M
N
S
Q
Y
Rat
Rattus norvegicus
NP_001011959
456
51197
R353
H
I
P
E
S
L
P
R
W
D
M
C
N
L
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026662
471
53136
Y366
N
R
S
Y
K
R
L
Y
M
Q
M
N
D
Q
Y
Frog
Xenopus laevis
NP_001088109
470
52915
Y365
Y
S
T
Y
G
R
I
Y
Q
S
M
K
D
H
Y
Zebra Danio
Brachydanio rerio
NP_956844
471
53005
F366
N
L
N
Y
N
R
L
F
M
D
V
K
K
Q
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52717
469
53628
Q368
V
T
T
T
Y
Q
K
Q
Y
T
D
M
T
P
F
Sea Urchin
Strong. purpuratus
XP_798670
470
52291
T369
C
S
A
L
P
Y
K
T
I
Y
A
T
M
Y
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L7B2
497
55814
D395
G
K
L
S
F
Y
H
D
A
G
S
M
I
D
F
Baker's Yeast
Sacchar. cerevisiae
P38109
508
57620
G389
G
F
L
F
T
G
D
G
S
K
P
F
Q
Q
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.9
94.5
N.A.
N.A.
86.8
78.3
N.A.
N.A.
65.8
61.6
63.1
N.A.
N.A.
N.A.
39.3
47.2
Protein Similarity:
100
95.1
94.9
N.A.
N.A.
92
84.7
N.A.
N.A.
77.7
75.8
77
N.A.
N.A.
N.A.
58.9
65.4
P-Site Identity:
100
100
100
N.A.
N.A.
93.3
6.6
N.A.
N.A.
60
40
46.6
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
100
100
100
N.A.
N.A.
100
26.6
N.A.
N.A.
66.6
53.3
60
N.A.
N.A.
N.A.
26.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.4
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
57.7
44.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
0
0
9
0
9
0
0
0
0
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% C
% Asp:
0
0
0
0
0
0
9
9
0
17
9
0
17
9
9
% D
% Glu:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
9
0
9
9
0
0
9
0
0
0
9
0
0
17
% F
% Gly:
17
0
0
0
9
9
0
9
0
9
0
0
0
0
0
% G
% His:
9
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% H
% Ile:
0
9
0
0
0
0
9
0
9
0
0
0
9
0
0
% I
% Lys:
0
9
0
0
9
0
17
0
0
9
0
17
9
0
0
% K
% Leu:
0
42
17
9
0
9
50
0
0
0
0
0
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
17
0
59
17
9
0
9
% M
% Asn:
50
0
9
0
9
0
0
0
0
0
0
42
9
0
0
% N
% Pro:
0
0
9
0
9
0
9
0
0
0
9
0
0
9
0
% P
% Gln:
0
0
34
0
0
9
0
9
17
9
0
0
9
59
0
% Q
% Arg:
0
9
0
0
34
59
0
9
25
0
0
0
0
0
0
% R
% Ser:
0
17
9
9
9
0
0
0
9
42
9
0
34
0
0
% S
% Thr:
0
9
17
9
9
0
0
9
0
9
0
9
9
0
0
% T
% Val:
9
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% W
% Tyr:
9
0
0
59
9
17
0
50
9
9
0
0
0
9
67
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _