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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CTSA All Species: 40
Human Site: Y395 Identified Species: 80
UniProt: P10619 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10619 NP_000299.2 480 54466 Y395 Q K Y Q I L L Y N G D V D M A
Chimpanzee Pan troglodytes XP_001159669 495 55859 Y410 Q K Y Q I L L Y N G D V D M A
Rhesus Macaque Macaca mulatta XP_001106032 494 55727 Y409 Q K Y Q I L L Y N G D V D M A
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P16675 474 53826 Y389 Q K Y Q I L L Y N G D V D M A
Rat Rattus norvegicus NP_001011959 456 51197 S374 R L Y E S M N S Q Y L K L L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026662 471 53136 Y387 M K Y R I L V Y N G D V D M A
Frog Xenopus laevis NP_001088109 470 52915 Y386 M K Y R I L V Y N G D V D M A
Zebra Danio Brachydanio rerio NP_956844 471 53005 Y387 L K Y R V L V Y N G D V D M A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52717 469 53628 Y389 N H V R V L L Y Y G D T D M A
Sea Urchin Strong. purpuratus XP_798670 470 52291 Y390 T Q Y R G L V Y N G D T D M A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L7B2 497 55814 Y416 S G Y R A L I Y S G D H D M C
Baker's Yeast Sacchar. cerevisiae P38109 508 57620 Y410 H N I P V L I Y A G D K D Y I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 94.5 N.A. N.A. 86.8 78.3 N.A. N.A. 65.8 61.6 63.1 N.A. N.A. N.A. 39.3 47.2
Protein Similarity: 100 95.1 94.9 N.A. N.A. 92 84.7 N.A. N.A. 77.7 75.8 77 N.A. N.A. N.A. 58.9 65.4
P-Site Identity: 100 100 100 N.A. N.A. 100 6.6 N.A. N.A. 80 80 73.3 N.A. N.A. N.A. 53.3 60
P-Site Similarity: 100 100 100 N.A. N.A. 100 40 N.A. N.A. 93.3 93.3 93.3 N.A. N.A. N.A. 66.6 80
Percent
Protein Identity: N.A. N.A. N.A. 37.4 28.5 N.A.
Protein Similarity: N.A. N.A. N.A. 57.7 44.6 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 0 9 0 0 0 0 0 75 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 92 0 92 0 0 % D
% Glu: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 0 0 9 0 0 0 0 92 0 0 0 0 0 % G
% His: 9 9 0 0 0 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 0 0 9 0 50 0 17 0 0 0 0 0 0 0 9 % I
% Lys: 0 59 0 0 0 0 0 0 0 0 0 17 0 0 0 % K
% Leu: 9 9 0 0 0 92 42 0 0 0 9 0 9 9 0 % L
% Met: 17 0 0 0 0 9 0 0 0 0 0 0 0 84 0 % M
% Asn: 9 9 0 0 0 0 9 0 67 0 0 0 0 0 0 % N
% Pro: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 34 9 0 34 0 0 0 0 9 0 0 0 0 0 0 % Q
% Arg: 9 0 0 50 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 0 0 0 9 0 0 9 9 0 0 0 0 0 9 % S
% Thr: 9 0 0 0 0 0 0 0 0 0 0 17 0 0 0 % T
% Val: 0 0 9 0 25 0 34 0 0 0 0 59 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 84 0 0 0 0 92 9 9 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _