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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP2C8
All Species:
11.82
Human Site:
Y358
Identified Species:
43.33
UniProt:
P10632
Number Species:
6
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10632
NP_000761.3
490
55825
Y358
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
Chimpanzee
Pan troglodytes
XP_001153207
490
55608
Y358
V
V
H
E
I
Q
R
Y
S
D
L
V
P
T
G
Rhesus Macaque
Macaca mulatta
Q6GUQ4
493
56626
F360
V
V
H
E
I
Q
R
F
I
T
L
V
P
S
N
Dog
Lupus familis
XP_534973
490
55872
Y358
V
V
H
E
I
Q
R
Y
I
D
L
V
P
N
N
Cat
Felis silvestris
Mouse
Mus musculus
P56656
490
55884
F358
M
I
H
E
V
Q
R
F
I
N
L
V
P
N
N
Rat
Rattus norvegicus
P33273
490
55972
Y358
M
V
H
E
I
Q
R
Y
I
N
L
I
P
N
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P20678
491
56467
F359
V
I
H
E
I
Q
R
F
I
D
F
L
P
V
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
56.3
66.3
N.A.
71.6
73.4
N.A.
N.A.
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.7
73.8
82.4
N.A.
83.6
84.2
N.A.
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
66.6
80
N.A.
46.6
60
N.A.
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
80
80
N.A.
80
80
N.A.
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
58
0
0
0
0
0
% D
% Glu:
0
0
0
100
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
43
0
0
15
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
29
% G
% His:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
29
0
0
86
0
0
0
72
0
0
15
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
86
15
0
0
0
% L
% Met:
29
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
29
0
0
0
43
72
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
0
% P
% Gln:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
100
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
29
0
0
0
0
15
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
15
0
0
0
29
0
% T
% Val:
72
72
0
0
15
0
0
0
0
0
0
72
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
58
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _