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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAPT
All Species:
13.33
Human Site:
S228
Identified Species:
32.59
UniProt:
P10636
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10636
NP_001116538.1
758
78878
S228
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
Chimpanzee
Pan troglodytes
Q5YCW1
776
80960
S228
D
R
D
V
D
E
S
S
L
Q
D
S
P
P
S
Rhesus Macaque
Macaca mulatta
P57786
459
47954
Dog
Lupus familis
XP_850032
783
81479
S227
D
R
D
V
D
E
S
S
P
Q
D
S
P
P
S
Cat
Felis silvestris
Mouse
Mus musculus
P10637
733
76225
S202
D
L
T
V
D
E
S
S
Q
D
S
P
P
S
Q
Rat
Rattus norvegicus
P19332
752
78545
S218
D
I
T
M
D
E
S
S
Q
E
S
P
P
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517812
273
28571
Chicken
Gallus gallus
XP_424354
421
43925
Frog
Xenopus laevis
NP_001082230
673
71638
D165
E
G
W
E
E
Q
V
D
E
G
C
E
M
R
Q
Zebra Danio
Brachydanio rerio
XP_001919266
309
32052
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.9
56
81
N.A.
74.5
74.4
N.A.
32.8
47.7
39.3
29.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
97
57.7
83.7
N.A.
80.8
80.2
N.A.
34.8
51.3
53.2
36.4
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
0
100
N.A.
46.6
40
N.A.
0
0
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
93.3
0
100
N.A.
46.6
53.3
N.A.
0
0
20
0
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% C
% Asp:
50
0
30
0
50
0
0
10
0
10
30
0
0
0
0
% D
% Glu:
10
0
0
10
10
50
0
0
10
10
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
0
0
0
0
0
0
10
0
0
0
0
0
0
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
20
0
0
20
50
30
0
% P
% Gln:
0
0
0
0
0
10
0
0
20
30
0
0
0
0
30
% Q
% Arg:
0
30
0
0
0
0
0
0
0
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
0
0
50
50
0
0
20
30
0
20
30
% S
% Thr:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
40
0
0
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _