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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALPPL2
All Species:
36.06
Human Site:
Y295
Identified Species:
66.11
UniProt:
P10696
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10696
NP_112603.2
532
57377
Y295
F
E
P
G
D
M
K
Y
E
I
H
R
D
S
T
Chimpanzee
Pan troglodytes
XP_001146156
534
57545
X297
D
A
P
X
X
X
X
X
X
X
X
X
D
S
T
Rhesus Macaque
Macaca mulatta
XP_001109717
652
71041
Y425
F
E
P
G
D
M
E
Y
E
L
N
R
N
N
V
Dog
Lupus familis
XP_534605
554
59751
Y298
F
E
P
G
D
T
K
Y
D
V
H
R
D
G
I
Cat
Felis silvestris
Mouse
Mus musculus
P24823
529
57193
Y294
F
E
P
N
D
M
K
Y
E
I
H
R
D
P
A
Rat
Rattus norvegicus
P15693
540
58384
Y296
F
E
P
T
E
M
K
Y
D
V
N
R
N
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q92058
519
56742
Y296
F
E
P
G
D
M
V
Y
E
L
D
R
N
N
E
Frog
Xenopus laevis
NP_001091135
530
58155
Y297
F
E
P
S
D
M
K
Y
E
L
N
R
N
T
T
Zebra Danio
Brachydanio rerio
NP_001020359
521
56944
Y295
F
E
P
K
D
T
R
Y
E
L
E
R
D
P
K
Tiger Blowfish
Takifugu rubipres
NP_001027823
527
57490
Y300
F
E
P
E
D
M
T
Y
D
L
E
R
N
P
E
Fruit Fly
Dros. melanogaster
Q24238
596
65244
Y333
F
R
N
N
H
I
T
Y
S
I
A
R
E
A
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130844
524
57641
Y297
F
E
P
G
D
M
Q
Y
E
L
N
R
N
N
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P11491
566
62986
F284
F
A
D
N
D
I
P
F
E
I
D
R
D
E
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.5
47.3
70.7
N.A.
73.8
72
N.A.
N.A.
56.2
59.9
56.2
54.3
40.2
N.A.
N.A.
N.A.
Protein Similarity:
100
94.3
59.2
79
N.A.
83.6
82.5
N.A.
N.A.
71
74.6
71.4
68.9
53.5
N.A.
N.A.
N.A.
P-Site Identity:
100
26.6
60
66.6
N.A.
80
46.6
N.A.
N.A.
60
66.6
53.3
46.6
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
93.3
80
N.A.
80
93.3
N.A.
N.A.
80
93.3
66.6
66.6
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
56.5
N.A.
N.A.
25.6
N.A.
Protein Similarity:
N.A.
72.1
N.A.
N.A.
41.7
N.A.
P-Site Identity:
N.A.
60
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
93.3
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
0
0
0
0
8
0
0
16
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
77
0
0
0
24
0
16
0
47
0
0
% D
% Glu:
0
77
0
8
8
0
8
0
62
0
16
0
8
8
16
% E
% Phe:
93
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
39
0
0
0
0
0
0
0
0
0
8
8
% G
% His:
0
0
0
0
8
0
0
0
0
0
24
0
0
0
0
% H
% Ile:
0
0
0
0
0
16
0
0
0
31
0
0
0
0
8
% I
% Lys:
0
0
0
8
0
0
39
0
0
0
0
0
0
0
16
% K
% Leu:
0
0
0
0
0
0
0
0
0
47
0
0
0
0
8
% L
% Met:
0
0
0
0
0
62
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
24
0
0
0
0
0
0
31
0
47
24
0
% N
% Pro:
0
0
85
0
0
0
8
0
0
0
0
0
0
24
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
8
0
0
0
0
93
0
0
0
% R
% Ser:
0
0
0
8
0
0
0
0
8
0
0
0
0
16
8
% S
% Thr:
0
0
0
8
0
16
16
0
0
0
0
0
0
8
24
% T
% Val:
0
0
0
0
0
0
8
0
0
16
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _