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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UROS All Species: 13.33
Human Site: Y128 Identified Species: 41.9
UniProt: P10746 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10746 NP_000366.1 265 28628 Y128 N A E K L A E Y I C S R E S S
Chimpanzee Pan troglodytes XP_508102 265 28641 Y128 N A E K L A E Y I C S R E S S
Rhesus Macaque Macaca mulatta XP_001086303 265 28634 Y128 N A E K L A E Y I C S R E S S
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P51163 265 28485 Y128 N A E K L A E Y I C S K P S S
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572507 277 30877 F129 G D Y I V D T F D G S R A L P
Honey Bee Apis mellifera XP_392378 266 29625 I133 A E L L V A S I E K K S K P L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_791243 313 34446 I127 N A E N L C K I I L E E W N S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P06174 275 30893 D135 L A D I I I D D L S T D I K A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 98.1 N.A. N.A. 77.7 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 31.4 33 N.A. 33.2
Protein Similarity: 100 100 99.6 N.A. N.A. 87.1 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 45.4 50 N.A. 49.5
P-Site Identity: 100 100 100 N.A. N.A. 86.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 13.3 6.6 N.A. 40
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 N.A. N.A. N.A. N.A. N.A. N.A. N.A. 26.6 20 N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 75 0 0 0 63 0 0 0 0 0 0 13 0 13 % A
% Cys: 0 0 0 0 0 13 0 0 0 50 0 0 0 0 0 % C
% Asp: 0 13 13 0 0 13 13 13 13 0 0 13 0 0 0 % D
% Glu: 0 13 63 0 0 0 50 0 13 0 13 13 38 0 0 % E
% Phe: 0 0 0 0 0 0 0 13 0 0 0 0 0 0 0 % F
% Gly: 13 0 0 0 0 0 0 0 0 13 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 25 13 13 0 25 63 0 0 0 13 0 0 % I
% Lys: 0 0 0 50 0 0 13 0 0 13 13 13 13 13 0 % K
% Leu: 13 0 13 13 63 0 0 0 13 13 0 0 0 13 13 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 63 0 0 13 0 0 0 0 0 0 0 0 0 13 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 13 13 13 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 50 0 0 0 % R
% Ser: 0 0 0 0 0 0 13 0 0 13 63 13 0 50 63 % S
% Thr: 0 0 0 0 0 0 13 0 0 0 13 0 0 0 0 % T
% Val: 0 0 0 0 25 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % W
% Tyr: 0 0 13 0 0 0 0 50 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _