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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CD28
All Species:
19.99
Human Site:
Y218
Identified Species:
54.97
UniProt:
P10747
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P10747
NP_006130.1
220
25066
Y218
P
P
R
D
F
A
A
Y
R
S
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_525998
234
26168
Y232
P
P
R
D
F
A
A
Y
R
S
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
NP_001036106
220
25008
Y218
P
P
R
D
F
A
A
Y
R
S
_
_
_
_
_
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31041
218
25161
Y216
P
A
R
D
F
A
A
Y
R
P
_
_
_
_
_
Rat
Rattus norvegicus
P31042
218
25152
Y216
P
A
R
D
F
A
A
Y
R
P
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513234
161
18321
Chicken
Gallus gallus
P31043
221
25383
Y216
P
T
R
D
Y
T
A
Y
R
S
W
Q
P
_
_
Frog
Xenopus laevis
NP_001091201
205
22904
Zebra Danio
Brachydanio rerio
XP_001343707
226
25142
Y223
M
L
S
Q
K
E
S
Y
V
K
F
_
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88.4
98.1
N.A.
N.A.
68.1
70.4
N.A.
45
50.2
33.6
20.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
91.4
98.6
N.A.
N.A.
76.8
78.6
N.A.
51.3
63.7
51.3
39.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
N.A.
N.A.
80
80
N.A.
0
53.8
0
9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
N.A.
N.A.
80
80
N.A.
0
61.5
0
18.1
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
23
0
0
0
56
67
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
67
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
56
0
0
0
0
0
12
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
12
0
0
0
0
12
0
0
0
0
0
% K
% Leu:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
67
34
0
0
0
0
0
0
0
23
0
0
12
0
0
% P
% Gln:
0
0
0
12
0
0
0
0
0
0
0
12
0
0
0
% Q
% Arg:
0
0
67
0
0
0
0
0
67
0
0
0
0
0
0
% R
% Ser:
0
0
12
0
0
0
12
0
0
45
0
0
0
0
0
% S
% Thr:
0
12
0
0
0
12
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% W
% Tyr:
0
0
0
0
12
0
0
78
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
56
67
67
78
78
% _