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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ESD All Species: 36.36
Human Site: S144 Identified Species: 61.54
UniProt: P10768 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10768 NP_001975.1 282 31463 S144 P V D P Q R M S I F G H S M G
Chimpanzee Pan troglodytes XP_001150093 316 35212 S178 P V D P Q R M S I F G H S M G
Rhesus Macaque Macaca mulatta XP_001097371 259 28732 P140 N A N F P V D P Q R M S V F G
Dog Lupus familis XP_848369 282 31374 S144 P V D P Q R M S I F G H S M G
Cat Felis silvestris
Mouse Mus musculus Q9R0P3 282 31301 S144 P V D P Q R M S I F G H S M G
Rat Rattus norvegicus B0BNE5 282 31345 S144 P V D P Q R I S I F G H S M G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513718 282 31435 S144 P T D P E R V S I F G H S M G
Chicken Gallus gallus
Frog Xenopus laevis NP_001087760 282 31523 S144 P A D P D R A S I F G H S M G
Zebra Danio Brachydanio rerio NP_001017796 282 31153 S144 P A D P E K M S I S G H S M G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_732486 330 36334 G189 P V V P G K R G I F G H S M G
Honey Bee Apis mellifera XP_395656 286 32137 S145 P V L P Y K Q S I M G H S M G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198332 281 31170 A145 P V N P D K V A I T G H S M G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8LAS8 284 31637 S147 Q L D T T K A S I S G H S M G
Baker's Yeast Sacchar. cerevisiae P40363 299 33916 A156 L D F L D N V A I T G H S M G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 88.9 90 96.4 N.A. 91.8 91.1 N.A. 88.3 N.A. 81.2 80.5 N.A. 50.9 65.7 N.A. 60.6
Protein Similarity: 100 88.9 91.1 98.5 N.A. 96.4 95.7 N.A. 95 N.A. 89.7 91.4 N.A. 63.9 78.3 N.A. 77.3
P-Site Identity: 100 100 6.6 100 N.A. 100 93.3 N.A. 80 N.A. 80 73.3 N.A. 66.6 66.6 N.A. 60
P-Site Similarity: 100 100 13.3 100 N.A. 100 100 N.A. 93.3 N.A. 80 86.6 N.A. 73.3 73.3 N.A. 86.6
Percent
Protein Identity: N.A. N.A. N.A. 56.6 39.8 N.A.
Protein Similarity: N.A. N.A. N.A. 71.8 58.1 N.A.
P-Site Identity: N.A. N.A. N.A. 53.3 40 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 22 0 0 0 0 15 15 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 65 0 22 0 8 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 15 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 8 8 0 0 0 0 0 58 0 0 0 8 0 % F
% Gly: 0 0 0 0 8 0 0 8 0 0 93 0 0 0 100 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 93 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 93 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 36 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 8 8 8 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 36 0 0 8 8 0 0 93 0 % M
% Asn: 8 0 15 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 79 0 0 79 8 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 36 0 8 0 8 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 50 8 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 72 0 15 0 8 93 0 0 % S
% Thr: 0 8 0 8 8 0 0 0 0 15 0 0 0 0 0 % T
% Val: 0 58 8 0 0 8 22 0 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _