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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: THRB All Species: 21.82
Human Site: T62 Identified Species: 53.33
UniProt: P10828 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10828 NP_000452.2 461 52788 T62 S P H L I Q T T W T S S I F H
Chimpanzee Pan troglodytes XP_001163991 467 53531 T68 S P H L I Q T T W T S S I F H
Rhesus Macaque Macaca mulatta XP_001090554 461 52739 T62 S P H L I Q A T W T S S I F H
Dog Lupus familis XP_862690 467 53497 T68 S P H L I Q A T W T S S I F H
Cat Felis silvestris
Mouse Mus musculus P37242 461 52611 T62 S P H L I Q A T W T S S I F H
Rat Rattus norvegicus P18113 461 52637 T62 S S H L I Q A T W A S S I F H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P04625 408 46739 K57 Q C V V C G D K A T G Y H Y R
Frog Xenopus laevis P18117 373 42282 K25 L C V V C G D K A T G Y H Y R
Zebra Danio Brachydanio rerio Q9PVE4 395 45137 I47 T G Y H Y R C I T C E G C K G
Tiger Blowfish Takifugu rubipres Q9W5Z3 447 49514 Y77 P P P P P R V Y K P C F V C Q
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 99.7 96.3 N.A. 96.5 95.8 N.A. N.A. 72.6 76.1 75 33.6 N.A. N.A. N.A. N.A.
Protein Similarity: 100 97.8 99.7 97.2 N.A. 97.6 96.9 N.A. N.A. 79.6 78.5 79.8 49.4 N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 93.3 N.A. 93.3 80 N.A. N.A. 6.6 6.6 0 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 80 N.A. N.A. 20 20 20 20 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 40 0 20 10 0 0 0 0 0 % A
% Cys: 0 20 0 0 20 0 10 0 0 10 10 0 10 10 0 % C
% Asp: 0 0 0 0 0 0 20 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 10 0 60 0 % F
% Gly: 0 10 0 0 0 20 0 0 0 0 20 10 0 0 10 % G
% His: 0 0 60 10 0 0 0 0 0 0 0 0 20 0 60 % H
% Ile: 0 0 0 0 60 0 0 10 0 0 0 0 60 0 0 % I
% Lys: 0 0 0 0 0 0 0 20 10 0 0 0 0 10 0 % K
% Leu: 10 0 0 60 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 60 10 10 10 0 0 0 0 10 0 0 0 0 0 % P
% Gln: 10 0 0 0 0 60 0 0 0 0 0 0 0 0 10 % Q
% Arg: 0 0 0 0 0 20 0 0 0 0 0 0 0 0 20 % R
% Ser: 60 10 0 0 0 0 0 0 0 0 60 60 0 0 0 % S
% Thr: 10 0 0 0 0 0 20 60 10 70 0 0 0 0 0 % T
% Val: 0 0 20 20 0 0 10 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 60 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 10 0 0 10 0 0 0 20 0 20 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _