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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IAPP All Species: 4.55
Human Site: T23 Identified Species: 20
UniProt: P10997 Number Species: 5
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10997 NP_000406.1 89 9806 T23 A L N H L K A T P I E S H Q V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001098180 89 9883 T23 A L N H L K A T P I E S H Q V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P12968 93 10003 R27 H L R A T P V R S G S N P Q M
Rat Rattus norvegicus P12969 93 9996 G27 H L R A T P V G S G T N P Q V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P10286 125 13710 F23 V V C Q M D S F Q A A P V R P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002661886 111 12347 L17 V P H N R Y S L P S I E R P D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.6 N.A. N.A. 64.5 64.5 N.A. N.A. 20 N.A. 42.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 N.A. 96.6 N.A. N.A. 76.3 75.2 N.A. N.A. 36.7 N.A. 56.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 N.A. 100 N.A. N.A. 13.3 20 N.A. N.A. 0 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 100 N.A. N.A. 26.6 26.6 N.A. N.A. 26.6 N.A. 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 34 0 0 34 0 0 34 0 0 17 17 0 0 0 0 % A
% Cys: 0 0 17 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 17 0 0 0 0 0 0 0 0 17 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 34 17 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 17 0 34 0 0 0 0 0 % G
% His: 34 0 17 34 0 0 0 0 0 0 0 0 34 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 34 17 0 0 0 0 % I
% Lys: 0 0 0 0 0 34 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 67 0 0 34 0 0 17 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 17 0 0 0 0 0 0 0 0 0 17 % M
% Asn: 0 0 34 17 0 0 0 0 0 0 0 34 0 0 0 % N
% Pro: 0 17 0 0 0 34 0 0 50 0 0 17 34 17 17 % P
% Gln: 0 0 0 17 0 0 0 0 17 0 0 0 0 67 0 % Q
% Arg: 0 0 34 0 17 0 0 17 0 0 0 0 17 17 0 % R
% Ser: 0 0 0 0 0 0 34 0 34 17 17 34 0 0 0 % S
% Thr: 0 0 0 0 34 0 0 34 0 0 17 0 0 0 0 % T
% Val: 34 17 0 0 0 0 34 0 0 0 0 0 17 0 50 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 17 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _