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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSPA5
All Species:
34.24
Human Site:
S354
Identified Species:
53.81
UniProt:
P11021
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11021
NP_005338.1
654
72333
S354
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
Chimpanzee
Pan troglodytes
XP_001144115
615
68321
K340
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_537847
666
73644
S354
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
Cat
Felis silvestris
Mouse
Mus musculus
P20029
655
72404
S355
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
Rat
Rattus norvegicus
P06761
654
72328
S354
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90593
652
72000
S352
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
Frog
Xenopus laevis
Q91883
658
72617
S355
D
D
S
D
L
K
K
S
D
I
D
E
I
V
L
Zebra Danio
Brachydanio rerio
NP_998223
650
71956
P352
E
D
S
D
P
K
K
P
D
I
D
E
I
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29844
656
72242
K354
E
D
A
D
M
N
K
K
D
V
H
E
I
V
L
Honey Bee
Apis mellifera
NP_001153524
658
72847
K356
E
D
S
D
M
N
K
K
D
V
D
E
I
V
L
Nematode Worm
Caenorhab. elegans
P27420
661
73005
D359
E
D
S
D
L
K
K
D
D
V
H
E
I
V
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O24581
663
73138
S358
E
D
A
G
L
E
K
S
Q
I
H
E
I
V
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LKR3
669
73611
S360
D
D
A
G
L
Q
K
S
Q
I
D
E
I
V
L
Baker's Yeast
Sacchar. cerevisiae
P16474
682
74449
K374
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
Red Bread Mold
Neurospora crassa
P78695
661
72313
S363
K
D
A
K
V
S
K
S
E
I
D
D
I
V
L
Conservation
Percent
Protein Identity:
100
94
N.A.
97.4
N.A.
98.4
98.4
N.A.
N.A.
96.4
92.7
91.7
N.A.
80.6
80.8
77.4
N.A.
Protein Similarity:
100
94
N.A.
98
N.A.
99
99
N.A.
N.A.
98.6
96.1
96
N.A.
90.6
90.1
88.8
N.A.
P-Site Identity:
100
0
N.A.
100
N.A.
100
100
N.A.
N.A.
100
93.3
86.6
N.A.
60
73.3
80
N.A.
P-Site Similarity:
100
33.3
N.A.
100
N.A.
100
100
N.A.
N.A.
100
100
86.6
N.A.
80
86.6
86.6
N.A.
Percent
Protein Identity:
N.A.
67.8
N.A.
67.1
64.6
67
Protein Similarity:
N.A.
82.8
N.A.
80.5
77.8
81
P-Site Identity:
N.A.
66.6
N.A.
66.6
60
53.3
P-Site Similarity:
N.A.
80
N.A.
86.6
86.6
86.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
27
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
94
0
67
0
0
0
7
74
0
74
14
0
0
0
% D
% Glu:
67
0
0
0
0
14
0
0
7
0
0
80
0
0
7
% E
% Phe:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
67
0
0
94
0
0
% I
% Lys:
7
0
0
7
0
54
94
27
0
0
0
7
0
0
0
% K
% Leu:
0
7
0
0
67
0
0
0
0
0
0
0
0
7
94
% L
% Met:
0
0
0
0
14
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
14
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
7
0
0
7
7
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
0
7
0
0
14
0
7
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
67
0
7
7
0
60
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
7
0
0
0
0
34
0
0
7
94
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _