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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDHB
All Species:
36.67
Human Site:
S218
Identified Species:
62.05
UniProt:
P11177
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11177
NP_000916.2
359
39233
S218
E
F
P
P
E
A
Q
S
K
D
F
L
I
P
I
Chimpanzee
Pan troglodytes
XP_526215
341
37181
S200
E
F
P
P
E
A
Q
S
K
D
F
L
I
P
I
Rhesus Macaque
Macaca mulatta
XP_001096445
359
39245
S218
E
F
P
P
E
A
Q
S
K
D
F
L
I
P
I
Dog
Lupus familis
XP_533778
359
39231
S218
E
F
P
S
E
A
Q
S
K
D
F
L
I
P
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9D051
359
38919
S218
E
L
P
A
E
A
Q
S
K
D
F
L
I
P
I
Rat
Rattus norvegicus
P49432
359
38964
S218
E
L
P
T
E
A
Q
S
K
D
F
L
I
P
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_414404
359
38858
S218
E
M
S
E
Q
A
Q
S
K
D
F
V
V
P
I
Frog
Xenopus laevis
NP_001084345
360
39106
S218
E
L
S
E
Q
A
Q
S
K
D
F
V
I
P
I
Zebra Danio
Brachydanio rerio
NP_998319
359
39290
S218
E
M
S
E
E
V
Q
S
K
D
F
V
I
P
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651668
365
39333
D214
P
V
A
D
N
V
A
D
K
D
F
L
V
P
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O44451
352
38122
S210
P
V
G
D
E
V
L
S
D
D
F
V
V
P
I
Sea Urchin
Strong. purpuratus
XP_785251
1079
120383
Q218
E
M
S
E
E
A
M
Q
D
D
F
V
L
P
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q38799
363
39157
D221
P
I
S
E
E
A
L
D
S
S
F
C
L
P
I
Baker's Yeast
Sacchar. cerevisiae
P32473
366
40035
S224
E
I
S
E
E
A
L
S
P
E
F
T
L
P
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.9
99.7
96.3
N.A.
93.5
94.4
N.A.
N.A.
83.8
83.3
83.8
N.A.
64.6
N.A.
64.6
22.9
Protein Similarity:
100
94.9
99.7
98.8
N.A.
97.4
97.7
N.A.
N.A.
92.4
92.2
92.1
N.A.
76.9
N.A.
79.3
28.5
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
60
66.6
66.6
N.A.
40
N.A.
40
46.6
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
N.A.
80
80
73.3
N.A.
46.6
N.A.
53.3
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
57.3
57.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74.6
75.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
79
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
0
15
0
0
0
15
15
86
0
0
0
0
0
% D
% Glu:
79
0
0
43
79
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
29
0
0
0
0
0
0
0
0
100
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
15
0
0
0
0
0
0
0
0
0
0
58
0
93
% I
% Lys:
0
0
0
0
0
0
0
0
72
0
0
0
0
0
0
% K
% Leu:
0
22
0
0
0
0
22
0
0
0
0
50
22
0
0
% L
% Met:
0
22
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
22
0
43
22
0
0
0
0
8
0
0
0
0
100
0
% P
% Gln:
0
0
0
0
15
0
65
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
43
8
0
0
0
79
8
8
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
0
15
0
0
0
22
0
0
0
0
0
36
22
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _