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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDHB All Species: 53.64
Human Site: Y63 Identified Species: 90.77
UniProt: P11177 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11177 NP_000916.2 359 39233 Y63 L G E E V A Q Y D G A Y K V S
Chimpanzee Pan troglodytes XP_526215 341 37181 K50 A Q Y D G A Y K V S R G L W K
Rhesus Macaque Macaca mulatta XP_001096445 359 39245 Y63 L G E E V A Q Y D G A Y K V S
Dog Lupus familis XP_533778 359 39231 Y63 L G E E V A Q Y D G A Y K V S
Cat Felis silvestris
Mouse Mus musculus Q9D051 359 38919 Y63 L G E E V A Q Y D G A Y K V S
Rat Rattus norvegicus P49432 359 38964 Y63 L G E E V A Q Y D G A Y K V S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414404 359 38858 Y63 L G E E V A Q Y D G A Y K I S
Frog Xenopus laevis NP_001084345 360 39106 Y63 L G E E V A Q Y D G A Y K V S
Zebra Danio Brachydanio rerio NP_998319 359 39290 Y63 L G E E V A Q Y D G A Y K V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651668 365 39333 Y59 L G E E V A Q Y D G A Y K V S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O44451 352 38122 Y55 M G E E V A Q Y D G A Y K I S
Sea Urchin Strong. purpuratus XP_785251 1079 120383 Y63 M G E E V A L Y D G A Y K V S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38799 363 39157 Y66 M G E E V G Q Y Q G A Y K I T
Baker's Yeast Sacchar. cerevisiae P32473 366 40035 Y69 I G E E V A Q Y N G A Y K V S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.9 99.7 96.3 N.A. 93.5 94.4 N.A. N.A. 83.8 83.3 83.8 N.A. 64.6 N.A. 64.6 22.9
Protein Similarity: 100 94.9 99.7 98.8 N.A. 97.4 97.7 N.A. N.A. 92.4 92.2 92.1 N.A. 76.9 N.A. 79.3 28.5
P-Site Identity: 100 6.6 100 100 N.A. 100 100 N.A. N.A. 93.3 100 100 N.A. 100 N.A. 86.6 86.6
P-Site Similarity: 100 13.3 100 100 N.A. 100 100 N.A. N.A. 100 100 100 N.A. 100 N.A. 100 93.3
Percent
Protein Identity: N.A. N.A. N.A. 57.3 57.1 N.A.
Protein Similarity: N.A. N.A. N.A. 74.6 75.1 N.A.
P-Site Identity: N.A. N.A. N.A. 66.6 86.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 86.6 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 93 0 0 0 0 93 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 79 0 0 0 0 0 0 % D
% Glu: 0 0 93 93 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 93 0 0 8 8 0 0 0 93 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 0 0 0 22 0 % I
% Lys: 0 0 0 0 0 0 0 8 0 0 0 0 93 0 8 % K
% Leu: 65 0 0 0 0 0 8 0 0 0 0 0 8 0 0 % L
% Met: 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 0 86 0 8 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 86 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % T
% Val: 0 0 0 0 93 0 0 0 8 0 0 0 0 72 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 0 8 0 0 0 8 93 0 0 0 93 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _