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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1
All Species:
17.88
Human Site:
S97
Identified Species:
30.26
UniProt:
P11387
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11387
NP_003277.1
765
90726
S97
K
E
E
K
V
R
A
S
G
D
A
K
I
K
K
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
Y62
Q
L
E
H
K
G
P
Y
F
A
P
P
Y
E
P
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
S99
K
E
E
K
V
R
A
S
G
D
A
K
I
K
K
Dog
Lupus familis
XP_534420
1004
115318
S333
K
E
E
K
V
R
A
S
G
D
A
K
I
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q04750
767
90857
A99
K
E
E
K
I
R
A
A
G
D
A
K
I
K
K
Rat
Rattus norvegicus
Q9WUL0
767
90741
A99
K
E
E
K
I
R
A
A
G
D
A
K
I
K
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509816
781
92543
S115
K
E
E
K
G
R
L
S
G
D
A
K
I
K
K
Chicken
Gallus gallus
Frog
Xenopus laevis
P41512
829
98212
S160
K
K
E
E
K
M
K
S
S
S
G
G
V
K
V
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
K363
D
I
P
L
L
A
R
K
K
V
K
K
E
K
I
Honey Bee
Apis mellifera
XP_396203
973
114099
E277
I
K
H
E
V
K
E
E
S
V
S
Q
I
E
P
Nematode Worm
Caenorhab. elegans
O17966
806
94011
K167
K
E
R
R
K
K
E
K
R
E
K
K
E
R
K
Sea Urchin
Strong. purpuratus
XP_793285
879
100968
N254
L
N
Q
R
F
D
D
N
V
K
S
E
S
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
A234
P
L
E
K
N
S
S
A
D
Q
S
S
L
K
K
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
S82
P
S
P
P
A
K
K
S
A
T
S
K
P
K
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54.1
99
74.8
N.A.
97
97
N.A.
90.4
N.A.
75
N.A.
N.A.
49.6
53.5
54.8
45.3
Protein Similarity:
100
67.4
99.6
75.8
N.A.
98.6
98.6
N.A.
93.8
N.A.
82.7
N.A.
N.A.
62.3
64.4
69.1
58
P-Site Identity:
100
6.6
100
100
N.A.
86.6
86.6
N.A.
86.6
N.A.
26.6
N.A.
N.A.
13.3
13.3
26.6
0
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
86.6
N.A.
46.6
N.A.
N.A.
20
53.3
53.3
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
46.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
63.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
36
22
8
8
43
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
8
8
0
8
43
0
0
0
0
0
% D
% Glu:
0
50
65
15
0
0
15
8
0
8
0
8
15
15
0
% E
% Phe:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
8
0
0
43
0
8
8
0
0
0
% G
% His:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
15
0
0
0
0
0
0
0
50
0
8
% I
% Lys:
58
15
0
50
22
22
15
15
8
8
15
65
0
72
65
% K
% Leu:
8
15
0
8
8
0
8
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
8
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
15
0
15
8
0
0
8
0
0
0
8
8
8
0
15
% P
% Gln:
8
0
8
0
0
0
0
0
0
8
0
8
0
0
0
% Q
% Arg:
0
0
8
15
0
43
8
0
8
0
0
0
0
15
8
% R
% Ser:
0
8
0
0
0
8
8
43
15
8
29
8
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% T
% Val:
0
0
0
0
29
0
0
0
8
15
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _