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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1
All Species:
37.58
Human Site:
T258
Identified Species:
63.59
UniProt:
P11387
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11387
NP_003277.1
765
90726
T258
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
R172
E
E
A
E
K
L
Q
R
E
F
G
Y
C
I
L
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
T260
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Dog
Lupus familis
XP_534420
1004
115318
T497
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Cat
Felis silvestris
Mouse
Mus musculus
Q04750
767
90857
T260
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Rat
Rattus norvegicus
Q9WUL0
767
90741
T260
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509816
781
92543
T274
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Chicken
Gallus gallus
Frog
Xenopus laevis
P41512
829
98212
T314
P
K
A
E
E
V
A
T
F
F
A
K
M
L
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
T481
E
E
T
E
E
A
A
T
F
Y
A
K
M
L
N
Honey Bee
Apis mellifera
XP_396203
973
114099
T484
Q
D
T
E
E
V
A
T
F
Y
A
R
M
L
D
Nematode Worm
Caenorhab. elegans
O17966
806
94011
Q300
L
E
T
E
E
I
A
Q
F
Y
A
G
V
L
D
Sea Urchin
Strong. purpuratus
XP_793285
879
100968
V402
Y
E
P
L
P
N
S
V
K
F
F
Y
D
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
T410
I
E
Q
E
E
V
A
T
M
F
A
V
M
R
E
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
L192
A
G
F
F
A
A
L
L
E
S
D
H
A
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54.1
99
74.8
N.A.
97
97
N.A.
90.4
N.A.
75
N.A.
N.A.
49.6
53.5
54.8
45.3
Protein Similarity:
100
67.4
99.6
75.8
N.A.
98.6
98.6
N.A.
93.8
N.A.
82.7
N.A.
N.A.
62.3
64.4
69.1
58
P-Site Identity:
100
20
100
100
N.A.
100
100
N.A.
100
N.A.
100
N.A.
N.A.
60
66.6
46.6
6.6
P-Site Similarity:
100
46.6
100
100
N.A.
100
100
N.A.
100
N.A.
100
N.A.
N.A.
80
80
73.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
46.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
63.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
58
0
8
15
79
0
0
0
79
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
8
0
8
0
65
% D
% Glu:
15
36
0
86
79
0
0
0
15
0
0
0
0
0
15
% E
% Phe:
0
0
8
8
0
0
0
0
72
72
8
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
0
0
0
8
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
50
0
0
8
0
0
0
8
0
0
58
0
8
0
% K
% Leu:
8
0
0
8
0
8
8
8
0
0
0
0
0
72
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
72
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
15
% N
% Pro:
50
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
8
0
0
0
8
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
8
0
8
0
% R
% Ser:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% S
% Thr:
0
0
22
0
0
0
0
72
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
65
0
8
0
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
22
0
15
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _