KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP1
All Species:
26.67
Human Site:
T649
Identified Species:
45.13
UniProt:
P11387
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11387
NP_003277.1
765
90726
T649
K
S
M
M
N
L
Q
T
K
I
D
A
K
K
E
Chimpanzee
Pan troglodytes
A9Q1D5
601
69739
A495
Q
A
K
K
E
Q
V
A
E
A
R
A
E
L
R
Rhesus Macaque
Macaca mulatta
XP_001088021
767
90935
S651
K
S
M
M
N
L
Q
S
K
I
D
A
K
K
E
Dog
Lupus familis
XP_534420
1004
115318
S888
K
S
M
M
N
L
Q
S
K
I
D
A
K
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q04750
767
90857
S651
K
S
M
M
N
L
Q
S
K
I
D
A
K
K
D
Rat
Rattus norvegicus
Q9WUL0
767
90741
S651
K
S
M
M
N
L
Q
S
K
I
D
A
K
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509816
781
92543
T665
K
S
M
M
N
L
Q
T
K
I
D
A
K
K
D
Chicken
Gallus gallus
Frog
Xenopus laevis
P41512
829
98212
G705
K
S
M
M
N
L
Q
G
K
I
D
A
K
K
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30189
972
111670
S857
I
L
C
N
H
Q
R
S
V
P
K
S
H
E
K
Honey Bee
Apis mellifera
XP_396203
973
114099
I853
R
A
N
R
A
V
A
I
L
C
N
H
Q
R
S
Nematode Worm
Caenorhab. elegans
O17966
806
94011
Q694
K
G
F
D
E
S
M
Q
K
L
E
Q
K
I
K
Sea Urchin
Strong. purpuratus
XP_793285
879
100968
E763
K
Q
M
E
N
L
Q
E
K
I
D
K
K
H
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30181
916
102780
A794
A
Q
I
E
K
L
T
A
R
I
E
E
L
K
E
Baker's Yeast
Sacchar. cerevisiae
P04786
769
89977
S654
K
E
E
L
L
P
E
S
Q
L
K
E
W
L
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54.1
99
74.8
N.A.
97
97
N.A.
90.4
N.A.
75
N.A.
N.A.
49.6
53.5
54.8
45.3
Protein Similarity:
100
67.4
99.6
75.8
N.A.
98.6
98.6
N.A.
93.8
N.A.
82.7
N.A.
N.A.
62.3
64.4
69.1
58
P-Site Identity:
100
6.6
93.3
93.3
N.A.
86.6
86.6
N.A.
93.3
N.A.
86.6
N.A.
N.A.
0
0
20
60
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
100
N.A.
93.3
N.A.
N.A.
40
40
40
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.6
46.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
63.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
0
0
8
0
8
15
0
8
0
58
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
58
0
0
0
29
% D
% Glu:
0
8
8
15
15
0
8
8
8
0
15
15
8
8
36
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
8
8
8
0
% H
% Ile:
8
0
8
0
0
0
0
8
0
65
0
0
0
8
0
% I
% Lys:
72
0
8
8
8
0
0
0
65
0
15
8
65
58
15
% K
% Leu:
0
8
0
8
8
65
0
0
8
15
0
0
8
15
8
% L
% Met:
0
0
58
50
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
8
58
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% P
% Gln:
8
15
0
0
0
15
58
8
8
0
0
8
8
0
0
% Q
% Arg:
8
0
0
8
0
0
8
0
8
0
8
0
0
8
8
% R
% Ser:
0
50
0
0
0
8
0
43
0
0
0
8
0
0
8
% S
% Thr:
0
0
0
0
0
0
8
15
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
8
0
8
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _