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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
35.76
Human Site:
S1213
Identified Species:
56.19
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1213
Q
M
A
E
V
L
P
S
P
R
G
Q
R
V
I
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1244
Q
L
E
E
T
M
P
S
P
Y
G
R
R
I
I
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1230
Q
L
E
E
T
M
P
S
P
Y
G
R
R
V
I
Dog
Lupus familis
XP_537646
1532
174610
S1213
Q
M
A
E
V
L
P
S
P
C
G
K
R
V
I
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1211
M
C
A
D
V
L
P
S
P
R
G
K
R
V
I
Rat
Rattus norvegicus
P41516
1526
173202
S1210
Q
I
S
E
V
L
P
S
P
V
G
K
R
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S1244
Q
L
A
E
I
L
P
S
P
H
G
R
R
V
I
Chicken
Gallus gallus
O42130
1553
174974
S1214
Q
L
A
E
V
M
P
S
P
H
G
I
R
V
V
Frog
Xenopus laevis
NP_001082502
1579
178601
S1208
Q
L
Q
E
I
M
P
S
P
H
G
R
R
V
I
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
T1210
V
K
N
E
T
M
P
T
P
Q
G
R
R
V
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
Q1145
K
K
N
E
L
L
K
Q
R
D
T
K
L
S
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1208
A
E
V
R
V
I
E
K
K
T
W
Q
D
L
W
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
G1145
D
S
S
E
A
G
S
G
P
D
Y
N
Y
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S1161
T
P
K
S
L
W
L
S
D
L
E
S
L
D
K
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
E1127
R
I
W
S
L
T
K
E
R
Y
Q
K
L
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
53.3
60
86.6
N.A.
73.3
73.3
N.A.
73.3
66.6
60
46.6
N.A.
13.3
N.A.
13.3
13.3
P-Site Similarity:
100
80
80
93.3
N.A.
86.6
93.3
N.A.
93.3
86.6
86.6
73.3
N.A.
33.3
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
34
0
7
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
7
0
0
7
0
0
0
0
7
14
0
0
7
7
0
% D
% Glu:
0
7
14
74
0
0
7
7
0
0
7
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
7
0
7
0
0
67
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
20
0
0
0
0
0
% H
% Ile:
0
14
0
0
14
7
0
0
0
0
0
7
0
7
60
% I
% Lys:
7
14
7
0
0
0
14
7
7
0
0
34
0
0
14
% K
% Leu:
0
34
0
0
20
40
7
0
0
7
0
0
20
20
7
% L
% Met:
7
14
0
0
0
34
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
14
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
7
0
0
0
0
67
0
74
0
0
0
0
0
0
% P
% Gln:
54
0
7
0
0
0
0
7
0
7
7
14
0
0
0
% Q
% Arg:
7
0
0
7
0
0
0
0
14
14
0
34
67
0
0
% R
% Ser:
0
7
14
14
0
0
7
67
0
0
0
7
0
7
0
% S
% Thr:
7
0
0
0
20
7
0
7
0
7
7
0
0
0
0
% T
% Val:
7
0
7
0
40
0
0
0
0
7
0
0
0
60
7
% V
% Trp:
0
0
7
0
0
7
0
0
0
0
7
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
0
0
20
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _