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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
12.73
Human Site:
S1337
Identified Species:
20
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1337
L
D
S
D
E
D
F
S
D
F
D
E
K
T
D
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
E1384
K
Y
T
F
D
F
S
E
E
E
D
D
D
A
D
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
E1370
K
Y
T
F
D
F
S
E
E
E
D
D
D
A
D
Dog
Lupus familis
XP_537646
1532
174610
D1338
D
L
D
D
S
F
S
D
F
E
E
R
I
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1333
L
D
S
D
E
D
F
S
G
L
D
E
K
D
E
Rat
Rattus norvegicus
P41516
1526
173202
S1333
L
D
S
D
D
D
F
S
G
L
D
E
K
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S1367
L
S
S
D
S
D
S
S
D
S
D
G
K
D
S
Chicken
Gallus gallus
O42130
1553
174974
T1359
E
G
N
T
D
S
D
T
T
S
K
K
K
P
P
Frog
Xenopus laevis
NP_001082502
1579
178601
S1352
E
E
S
S
L
K
K
S
I
D
K
S
D
S
E
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
D1346
S
S
E
D
E
F
D
D
F
T
K
S
S
K
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
A1253
A
A
A
K
V
A
Q
A
A
K
E
P
K
K
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
M1322
G
Q
D
I
K
K
F
M
S
P
A
A
P
K
T
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
V1254
P
S
P
Y
G
R
R
V
A
P
R
I
D
N
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
N1236
S
A
M
D
T
D
N
N
V
A
E
V
V
K
P
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
L1235
R
I
L
L
E
Q
K
L
V
T
K
S
K
A
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
13.3
13.3
13.3
N.A.
73.3
66.6
N.A.
53.3
6.6
13.3
13.3
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
40
40
20
N.A.
80
80
N.A.
53.3
33.3
33.3
13.3
N.A.
26.6
N.A.
13.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
7
0
0
7
0
7
14
7
7
7
0
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
20
14
47
27
34
14
14
14
7
40
14
27
20
27
% D
% Glu:
14
7
7
0
27
0
0
14
14
20
20
20
0
0
20
% E
% Phe:
0
0
0
14
0
27
27
0
14
7
0
0
0
0
0
% F
% Gly:
7
7
0
0
7
0
0
0
14
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
7
0
0
0
0
7
0
0
7
7
0
0
% I
% Lys:
14
0
0
7
7
14
14
0
0
7
27
7
47
27
0
% K
% Leu:
27
7
7
7
7
0
0
7
0
14
0
0
0
0
7
% L
% Met:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
7
7
0
0
0
0
0
7
0
% N
% Pro:
7
0
7
0
0
0
0
0
0
14
0
7
7
7
27
% P
% Gln:
0
7
0
0
0
7
7
0
0
0
0
0
0
7
0
% Q
% Arg:
7
0
0
0
0
7
7
0
0
0
7
7
0
0
0
% R
% Ser:
14
20
34
7
14
7
27
34
7
14
0
20
7
7
7
% S
% Thr:
0
0
14
7
7
0
0
7
7
14
0
0
0
7
14
% T
% Val:
0
0
0
0
7
0
0
7
14
0
0
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
14
0
7
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _