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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
47.58
Human Site:
T1014
Identified Species:
74.76
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
T1014
G
C
L
K
K
Y
D
T
V
L
D
I
L
R
D
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1043
G
C
L
K
K
Y
E
T
V
Q
D
I
L
K
E
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1029
G
C
L
K
K
Y
E
T
V
Q
D
I
L
K
E
Dog
Lupus familis
XP_537646
1532
174610
T1014
G
C
L
K
K
Y
D
T
V
L
D
I
L
R
D
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
T1013
G
C
L
K
K
Y
D
T
V
L
D
I
L
R
D
Rat
Rattus norvegicus
P41516
1526
173202
T1012
G
C
L
K
K
Y
D
T
V
L
D
I
L
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
T1042
G
C
L
K
K
Y
D
T
A
L
D
I
L
R
D
Chicken
Gallus gallus
O42130
1553
174974
S1015
G
F
L
K
K
Y
E
S
P
Q
D
I
L
K
E
Frog
Xenopus laevis
NP_001082502
1579
178601
T1012
G
C
L
R
K
Y
E
T
V
L
D
I
L
R
E
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
S1017
G
S
L
K
K
Y
E
S
V
Q
D
I
L
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
T996
N
C
L
R
R
F
P
T
A
I
D
I
L
K
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
S1050
G
C
L
R
T
Y
T
S
P
E
A
I
T
Q
E
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
V996
D
T
T
V
K
F
V
V
K
M
N
E
D
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
T1004
G
V
I
K
K
Y
V
T
P
E
Q
I
L
E
E
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
M975
S
P
I
S
L
M
N
M
V
A
F
D
P
H
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
73.3
73.3
100
N.A.
100
100
N.A.
93.3
53.3
80
60
N.A.
40
N.A.
33.3
13.3
P-Site Similarity:
100
93.3
93.3
100
N.A.
100
100
N.A.
93.3
80
100
86.6
N.A.
80
N.A.
60
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
14
7
7
0
0
0
0
% A
% Cys:
0
67
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
34
0
0
0
74
7
7
0
34
% D
% Glu:
0
0
0
0
0
0
34
0
0
14
0
7
0
7
54
% E
% Phe:
0
7
0
0
0
14
0
0
0
0
7
0
0
0
0
% F
% Gly:
80
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
14
0
0
0
0
0
0
7
0
87
0
0
0
% I
% Lys:
0
0
0
67
80
0
0
0
7
0
0
0
0
34
0
% K
% Leu:
0
0
80
0
7
0
0
0
0
40
0
0
80
0
7
% L
% Met:
0
0
0
0
0
7
0
7
0
7
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% N
% Pro:
0
7
0
0
0
0
7
0
20
0
0
0
7
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
27
7
0
0
7
0
% Q
% Arg:
0
0
0
20
7
0
0
0
0
0
0
0
0
47
0
% R
% Ser:
7
7
0
7
0
0
0
20
0
0
0
0
0
0
0
% S
% Thr:
0
7
7
0
7
0
7
67
0
0
0
0
7
0
0
% T
% Val:
0
7
0
7
0
0
14
7
60
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
80
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _