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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
11.21
Human Site:
T1274
Identified Species:
17.62
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
T1274
K
R
E
P
G
T
K
T
K
K
Q
T
T
L
A
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
V1322
K
K
E
P
G
T
R
V
R
K
T
P
T
S
S
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
V1308
K
K
E
P
G
T
R
V
R
K
T
P
T
S
S
Dog
Lupus familis
XP_537646
1532
174610
T1274
K
R
E
P
G
T
K
T
K
K
Q
T
T
L
P
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
A1270
K
Q
K
K
E
P
G
A
K
K
Q
T
T
L
P
Rat
Rattus norvegicus
P41516
1526
173202
A1270
K
R
E
P
G
T
R
A
K
K
Q
T
T
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
G1304
K
S
D
T
G
T
K
G
K
K
Q
N
T
L
L
Chicken
Gallus gallus
O42130
1553
174974
T1278
K
R
K
A
E
Q
G
T
K
R
Q
T
T
L
P
Frog
Xenopus laevis
NP_001082502
1579
178601
D1286
P
G
T
K
A
V
K
D
K
K
Q
A
T
L
P
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
S1284
T
K
D
K
G
S
K
S
G
K
Q
T
T
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
N1191
R
A
E
E
Q
G
I
N
L
K
T
A
K
A
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
R1256
A
A
D
A
K
T
G
R
G
P
K
K
N
V
C
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
T1191
K
T
A
S
M
L
W
T
D
D
L
N
A
F
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
P1209
K
R
Q
A
P
K
K
P
A
P
K
K
T
T
K
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
D1173
Y
Q
E
F
L
Q
R
D
A
E
A
R
G
G
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
46.6
46.6
93.3
N.A.
46.6
80
N.A.
60
53.3
40
46.6
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
73.3
73.3
93.3
N.A.
60
86.6
N.A.
66.6
66.6
40
73.3
N.A.
20
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
14
7
20
7
0
0
14
14
0
7
14
7
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
20
0
0
0
0
14
7
7
0
0
0
0
0
% D
% Glu:
0
0
47
7
14
0
0
0
0
7
0
0
0
0
0
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
7
0
0
47
7
20
7
14
0
0
0
7
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% I
% Lys:
67
20
14
20
7
7
40
0
47
67
14
14
7
0
7
% K
% Leu:
0
0
0
0
7
7
0
0
7
0
7
0
0
54
14
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
0
14
7
0
7
% N
% Pro:
7
0
0
34
7
7
0
7
0
14
0
14
0
0
34
% P
% Gln:
0
14
7
0
7
14
0
0
0
0
54
0
0
0
0
% Q
% Arg:
7
34
0
0
0
0
27
7
14
7
0
7
0
0
0
% R
% Ser:
0
7
0
7
0
7
0
7
0
0
0
0
0
14
14
% S
% Thr:
7
7
7
7
0
47
0
27
0
0
20
40
74
7
7
% T
% Val:
0
0
0
0
0
7
0
14
0
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _