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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
4.24
Human Site:
T1415
Identified Species:
6.67
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
T1415
P
V
P
K
K
N
V
T
V
K
K
T
A
A
K
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1462
L
F
S
F
P
S
Y
S
Q
K
S
E
D
D
S
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1448
L
F
S
F
P
S
Y
S
Q
K
S
E
D
D
S
Dog
Lupus familis
XP_537646
1532
174610
D1416
P
L
P
K
K
K
V
D
V
K
K
I
A
P
K
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
G1411
K
P
S
K
K
T
V
G
V
K
K
T
A
T
K
Rat
Rattus norvegicus
P41516
1526
173202
G1411
P
S
S
K
Q
T
V
G
V
K
R
T
I
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
D1445
A
R
D
P
P
T
R
D
P
S
P
V
P
V
T
Chicken
Gallus gallus
O42130
1553
174974
S1437
T
A
K
D
N
Q
P
S
I
M
D
I
L
T
K
Frog
Xenopus laevis
NP_001082502
1579
178601
S1430
S
A
P
A
P
A
P
S
A
P
E
P
A
P
R
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
A1424
P
K
P
V
K
K
S
A
E
G
A
A
K
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
Q1331
E
N
G
G
G
L
K
Q
S
K
I
D
F
S
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
A1400
E
V
P
A
K
K
P
A
P
A
K
K
A
A
P
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
A1332
K
A
P
K
E
P
K
A
P
K
V
P
K
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
G1349
V
A
P
V
K
K
G
G
R
K
P
A
A
T
K
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
N1313
T
S
A
T
S
K
E
N
T
P
E
Q
D
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
6.6
6.6
66.6
N.A.
60
46.6
N.A.
0
6.6
13.3
20
N.A.
13.3
N.A.
40
26.6
P-Site Similarity:
100
20
20
73.3
N.A.
60
60
N.A.
0
20
33.3
20
N.A.
20
N.A.
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
27
7
14
0
7
0
20
7
7
7
14
40
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
0
0
0
14
0
0
7
7
20
20
0
% D
% Glu:
14
0
0
0
7
0
7
0
7
0
14
14
0
0
0
% E
% Phe:
0
14
0
14
0
0
0
0
0
0
0
0
7
0
0
% F
% Gly:
0
0
7
7
7
0
7
20
0
7
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
7
0
7
14
7
0
0
% I
% Lys:
14
7
7
34
40
34
14
0
0
60
27
7
14
7
47
% K
% Leu:
14
7
0
0
0
7
0
0
0
0
0
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
7
0
0
7
7
0
7
0
0
0
0
0
0
0
% N
% Pro:
27
7
47
7
27
7
20
0
20
14
14
14
7
14
20
% P
% Gln:
0
0
0
0
7
7
0
7
14
0
0
7
0
0
0
% Q
% Arg:
0
7
0
0
0
0
7
0
7
0
7
0
0
0
7
% R
% Ser:
7
14
27
0
7
14
7
27
7
7
14
0
0
7
14
% S
% Thr:
14
0
0
7
0
20
0
7
7
0
0
20
0
27
7
% T
% Val:
7
14
0
14
0
0
27
0
27
0
7
7
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
14
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _