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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
15.45
Human Site:
T1487
Identified Species:
24.29
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
T1487
K
I
V
S
K
A
V
T
S
K
K
S
K
G
E
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1534
A
V
N
S
D
S
D
S
E
F
G
I
P
K
K
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1520
A
V
N
S
D
S
D
S
E
F
G
I
P
K
K
Dog
Lupus familis
XP_537646
1532
174610
T1488
K
M
I
S
K
A
A
T
N
K
K
S
K
G
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
T1483
R
A
I
S
K
G
A
T
S
K
K
A
K
G
E
Rat
Rattus norvegicus
P41516
1526
173202
T1483
K
A
I
S
K
G
A
T
S
K
K
L
K
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
A1517
G
E
E
E
G
D
G
A
S
W
K
H
L
E
S
Chicken
Gallus gallus
O42130
1553
174974
K1509
S
V
A
A
K
K
S
K
R
D
D
D
D
S
Y
Frog
Xenopus laevis
NP_001082502
1579
178601
S1502
A
P
A
P
K
K
T
S
K
A
T
K
Q
Q
K
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
K1496
K
K
Q
A
K
K
R
K
S
V
L
S
S
D
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
R1403
S
P
K
R
P
A
K
R
G
R
E
D
E
S
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
D1472
K
K
A
A
G
S
D
D
E
D
D
E
S
F
V
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
R1404
A
Q
T
D
R
G
P
R
R
A
A
A
S
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
G1421
E
S
S
E
N
V
A
G
N
S
S
S
E
K
S
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
Q1385
I
P
Q
R
S
R
R
Q
R
S
S
R
A
A
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
6.6
6.6
73.3
N.A.
60
66.6
N.A.
13.3
6.6
6.6
26.6
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
33.3
33.3
93.3
N.A.
80
73.3
N.A.
13.3
20
26.6
40
N.A.
26.6
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
27
14
20
20
0
20
27
7
0
14
7
14
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
14
7
20
7
0
14
14
14
7
7
0
% D
% Glu:
7
7
7
14
0
0
0
0
20
0
7
7
14
7
27
% E
% Phe:
0
0
0
0
0
0
0
0
0
14
0
0
0
7
0
% F
% Gly:
7
0
0
0
14
20
7
7
7
0
14
0
0
27
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
7
7
20
0
0
0
0
0
0
0
0
14
0
0
0
% I
% Lys:
34
14
7
0
47
20
7
14
7
27
34
7
27
20
27
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
7
7
7
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
14
0
7
0
0
0
14
0
0
0
0
0
0
% N
% Pro:
0
20
0
7
7
0
7
0
0
0
0
0
14
0
0
% P
% Gln:
0
7
14
0
0
0
0
7
0
0
0
0
7
7
7
% Q
% Arg:
7
0
0
14
7
7
14
14
20
7
0
7
0
0
0
% R
% Ser:
14
7
7
40
7
20
7
20
34
14
14
27
20
14
27
% S
% Thr:
0
0
7
0
0
0
7
27
0
0
7
0
0
7
0
% T
% Val:
0
20
7
0
0
7
7
0
0
7
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _