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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
31.21
Human Site:
Y1082
Identified Species:
49.05
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
Y1082
K
V
L
I
Q
R
G
Y
D
S
D
P
V
K
A
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
Y1111
Q
M
L
V
Q
R
G
Y
E
S
D
P
V
K
A
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
Y1097
Q
M
L
V
Q
R
G
Y
E
S
D
P
V
K
A
Dog
Lupus familis
XP_537646
1532
174610
Y1082
K
V
L
I
Q
R
G
Y
D
S
D
P
V
K
A
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
Y1081
K
V
L
I
Q
R
G
Y
D
S
D
P
V
K
A
Rat
Rattus norvegicus
P41516
1526
173202
Y1080
K
V
L
I
Q
R
G
Y
D
S
D
P
V
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
Y1110
K
V
L
I
Q
R
G
Y
D
S
D
P
V
K
A
Chicken
Gallus gallus
O42130
1553
174974
P1070
K
I
V
I
E
N
K
P
K
K
E
L
I
Q
V
Frog
Xenopus laevis
NP_001082502
1579
178601
P1067
K
I
V
I
E
N
K
P
K
K
E
L
I
Q
M
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
Y1085
R
M
L
Q
Q
M
G
Y
D
S
D
P
V
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
E1042
R
F
I
L
E
K
C
E
K
K
L
V
V
E
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
N1096
R
F
I
L
A
K
I
N
N
E
I
V
L
E
N
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
V1042
C
I
R
R
Y
D
N
V
E
E
I
L
R
E
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
K1059
E
I
I
V
N
K
R
K
K
A
D
I
V
E
D
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
K1022
R
L
Q
W
E
V
E
K
Y
S
F
Q
V
K
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
73.3
73.3
100
N.A.
100
100
N.A.
100
13.3
13.3
73.3
N.A.
6.6
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
53.3
53.3
86.6
N.A.
46.6
N.A.
46.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
0
7
0
0
0
0
54
% A
% Cys:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
0
40
0
60
0
0
0
7
% D
% Glu:
7
0
0
0
27
0
7
7
20
14
14
0
0
27
0
% E
% Phe:
0
14
0
0
0
0
0
0
0
0
7
0
0
0
14
% F
% Gly:
0
0
0
0
0
0
54
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
27
20
47
0
0
7
0
0
0
14
7
14
0
0
% I
% Lys:
47
0
0
0
0
20
14
14
27
20
0
0
0
60
0
% K
% Leu:
0
7
54
14
0
0
0
0
0
0
7
20
7
0
0
% L
% Met:
0
20
0
0
0
7
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
0
0
0
7
14
7
7
7
0
0
0
0
0
14
% N
% Pro:
0
0
0
0
0
0
0
14
0
0
0
54
0
0
0
% P
% Gln:
14
0
7
7
54
0
0
0
0
0
0
7
0
14
0
% Q
% Arg:
27
0
7
7
0
47
7
0
0
0
0
0
7
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
60
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
34
14
20
0
7
0
7
0
0
0
14
74
0
7
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
54
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _