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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP19A1
All Species:
22.12
Human Site:
T268
Identified Species:
37.44
UniProt:
P11511
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11511
NP_000094.2
503
57883
T268
E
K
R
R
R
I
S
T
E
E
K
L
E
E
C
Chimpanzee
Pan troglodytes
XP_001169384
503
57882
T268
E
K
R
R
R
I
S
T
E
E
K
L
E
E
C
Rhesus Macaque
Macaca mulatta
XP_001082665
426
48911
W224
I
Q
G
Y
F
D
A
W
Q
A
L
L
I
K
P
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P28649
503
57997
T268
K
K
R
H
K
V
S
T
A
E
K
L
E
D
C
Rat
Rattus norvegicus
P22443
508
58393
S268
K
K
R
Q
K
V
S
S
A
E
K
L
E
D
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P19098
507
58128
T267
Q
K
R
Q
K
L
S
T
V
E
K
L
D
E
H
Frog
Xenopus laevis
NP_001079122
500
57333
S266
Q
K
R
Q
K
L
S
S
S
E
K
L
D
E
D
Zebra Danio
Brachydanio rerio
O42145
509
57336
A287
E
Q
K
K
V
Q
L
A
H
A
E
K
L
D
H
Tiger Blowfish
Takifugu rubipres
NP_001166967
531
59842
E270
V
K
R
K
L
V
H
E
A
E
K
L
D
D
V
Fruit Fly
Dros. melanogaster
Q27589
501
57896
K263
E
T
L
V
N
N
S
K
E
T
T
P
E
E
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09653
519
59999
D289
F
L
E
A
R
A
D
D
V
E
H
F
Q
E
N
Sea Urchin
Strong. purpuratus
XP_783176
459
52654
T252
H
R
E
D
A
T
F
T
L
E
D
I
R
E
E
Poplar Tree
Populus trichocarpa
XP_002318721
509
58015
E271
K
T
K
K
R
V
L
E
N
D
R
E
G
K
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_173862
522
61037
K276
E
R
R
N
K
M
R
K
L
G
N
L
N
D
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
82.6
N.A.
N.A.
79.3
75.9
N.A.
N.A.
71
69.7
49.9
49.9
26.2
N.A.
20.2
25
Protein Similarity:
100
100
84.4
N.A.
N.A.
90.8
88.7
N.A.
N.A.
85.8
83.3
71.9
67.8
47.3
N.A.
38.5
42.3
P-Site Identity:
100
100
6.6
N.A.
N.A.
60
53.3
N.A.
N.A.
53.3
46.6
6.6
33.3
33.3
N.A.
20
20
P-Site Similarity:
100
100
33.3
N.A.
N.A.
86.6
93.3
N.A.
N.A.
86.6
86.6
40
60
33.3
N.A.
26.6
33.3
Percent
Protein Identity:
24.5
N.A.
N.A.
25.6
N.A.
N.A.
Protein Similarity:
44.9
N.A.
N.A.
45.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
8
8
8
22
15
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
29
% C
% Asp:
0
0
0
8
0
8
8
8
0
8
8
0
22
36
8
% D
% Glu:
36
0
15
0
0
0
0
15
22
65
8
8
36
50
15
% E
% Phe:
8
0
0
0
8
0
8
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
8
0
0
8
0
0
% G
% His:
8
0
0
8
0
0
8
0
8
0
8
0
0
0
15
% H
% Ile:
8
0
0
0
0
15
0
0
0
0
0
8
8
0
0
% I
% Lys:
22
50
15
22
36
0
0
15
0
0
50
8
0
15
0
% K
% Leu:
0
8
8
0
8
15
15
0
15
0
8
65
8
0
8
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
8
0
0
8
0
8
0
8
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% P
% Gln:
15
15
0
22
0
8
0
0
8
0
0
0
8
0
0
% Q
% Arg:
0
15
58
15
29
0
8
0
0
0
8
0
8
0
0
% R
% Ser:
0
0
0
0
0
0
50
15
8
0
0
0
0
0
0
% S
% Thr:
0
15
0
0
0
8
0
36
0
8
8
0
0
0
0
% T
% Val:
8
0
0
8
8
29
0
0
15
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _