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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP19A1
All Species:
20.61
Human Site:
Y426
Identified Species:
34.87
UniProt:
P11511
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11511
NP_000094.2
503
57883
Y426
A
K
N
V
P
Y
R
Y
F
Q
P
F
G
F
G
Chimpanzee
Pan troglodytes
XP_001169384
503
57882
Y426
A
K
N
V
P
Y
R
Y
F
Q
P
F
G
F
G
Rhesus Macaque
Macaca mulatta
XP_001082665
426
48911
M350
R
D
V
K
I
D
D
M
Q
K
L
K
V
M
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P28649
503
57997
Y426
E
K
N
V
P
Y
R
Y
F
Q
P
F
G
F
G
Rat
Rattus norvegicus
P22443
508
58393
Y426
E
K
N
V
P
Y
R
Y
F
Q
P
F
G
F
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P19098
507
58128
Y425
E
K
N
V
P
S
R
Y
F
Q
P
F
G
F
G
Frog
Xenopus laevis
NP_001079122
500
57333
Y424
E
K
T
V
P
Y
R
Y
F
Q
P
F
G
S
G
Zebra Danio
Brachydanio rerio
O42145
509
57336
F426
R
M
H
R
S
E
F
F
S
K
P
N
Q
F
S
Tiger Blowfish
Takifugu rubipres
NP_001166967
531
59842
A430
E
Q
T
V
S
C
S
A
A
N
V
A
P
G
T
Fruit Fly
Dros. melanogaster
Q27589
501
57896
F422
Y
F
E
S
P
D
E
F
R
P
E
R
F
D
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09653
519
59999
R440
A
K
E
F
K
P
E
R
W
L
D
P
N
C
D
Sea Urchin
Strong. purpuratus
XP_783176
459
52654
L382
R
F
D
P
D
R
F
L
P
E
N
S
T
K
R
Poplar Tree
Populus trichocarpa
XP_002318721
509
58015
W423
F
E
F
R
P
D
R
W
F
Q
E
I
G
N
D
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_173862
522
61037
W444
E
E
F
K
P
E
R
W
I
K
E
G
R
I
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
82.6
N.A.
N.A.
79.3
75.9
N.A.
N.A.
71
69.7
49.9
49.9
26.2
N.A.
20.2
25
Protein Similarity:
100
100
84.4
N.A.
N.A.
90.8
88.7
N.A.
N.A.
85.8
83.3
71.9
67.8
47.3
N.A.
38.5
42.3
P-Site Identity:
100
100
0
N.A.
N.A.
93.3
93.3
N.A.
N.A.
86.6
80
13.3
6.6
6.6
N.A.
13.3
0
P-Site Similarity:
100
100
6.6
N.A.
N.A.
93.3
93.3
N.A.
N.A.
86.6
80
33.3
13.3
13.3
N.A.
20
13.3
Percent
Protein Identity:
24.5
N.A.
N.A.
25.6
N.A.
N.A.
Protein Similarity:
44.9
N.A.
N.A.
45.5
N.A.
N.A.
P-Site Identity:
33.3
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
22
0
0
0
0
0
0
8
8
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
8
0
8
22
8
0
0
0
8
0
0
8
15
% D
% Glu:
43
15
15
0
0
15
15
0
0
8
22
0
0
0
8
% E
% Phe:
8
15
15
8
0
0
15
15
50
0
0
43
8
43
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
50
8
43
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
8
0
0
8
0
8
0
% I
% Lys:
0
50
0
15
8
0
0
0
0
22
0
8
0
8
0
% K
% Leu:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% L
% Met:
0
8
0
0
0
0
0
8
0
0
0
0
0
8
0
% M
% Asn:
0
0
36
0
0
0
0
0
0
8
8
8
8
8
0
% N
% Pro:
0
0
0
8
65
8
0
0
8
8
50
8
8
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
8
50
0
0
8
0
0
% Q
% Arg:
22
0
0
15
0
8
58
8
8
0
0
8
8
0
8
% R
% Ser:
0
0
0
8
15
8
8
0
8
0
0
8
0
8
8
% S
% Thr:
0
0
15
0
0
0
0
0
0
0
0
0
8
0
8
% T
% Val:
0
0
8
50
0
0
0
0
0
0
8
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
15
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
36
0
43
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _