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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1
All Species:
41.52
Human Site:
S323
Identified Species:
76.11
UniProt:
P11586
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11586
NP_005947.3
935
101559
S323
V
P
S
D
I
D
I
S
R
S
C
K
P
K
P
Chimpanzee
Pan troglodytes
XP_001170520
978
105642
S379
V
P
S
D
I
D
I
S
R
S
C
K
P
K
P
Rhesus Macaque
Macaca mulatta
XP_001101889
921
99498
S322
V
P
S
D
I
D
I
S
R
S
C
K
L
K
P
Dog
Lupus familis
XP_537476
935
101232
S323
V
P
S
D
I
D
I
S
R
S
C
K
P
K
P
Cat
Felis silvestris
Mouse
Mus musculus
Q922D8
935
101237
S323
V
P
S
D
I
A
I
S
R
S
C
K
P
K
L
Rat
Rattus norvegicus
P27653
935
100977
S323
V
P
S
D
I
A
I
S
R
S
C
K
P
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034392
935
100213
S323
V
P
S
D
I
E
I
S
R
S
C
I
P
K
P
Frog
Xenopus laevis
NP_001080574
934
100531
S322
V
P
S
D
I
E
I
S
R
S
C
I
P
K
P
Zebra Danio
Brachydanio rerio
NP_955823
934
100443
S322
V
P
S
D
V
A
I
S
R
S
C
V
P
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
A356
V
P
S
D
I
V
I
A
R
A
Q
K
P
K
D
Honey Bee
Apis mellifera
XP_623070
937
101449
S325
V
P
S
D
I
T
I
S
R
N
Q
E
P
K
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
D66
D
E
L
Q
G
Q
E
D
G
Y
Y
V
V
V
G
Baker's Yeast
Sacchar. cerevisiae
P07245
946
102187
S327
V
P
S
D
I
D
I
S
R
A
Q
Q
P
K
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
94.7
94.4
N.A.
92.8
93.3
N.A.
N.A.
80.7
82.3
76.9
N.A.
59.8
62.4
N.A.
N.A.
Protein Similarity:
100
93.4
96.6
97.7
N.A.
97.7
97.4
N.A.
N.A.
91.3
92.8
88.3
N.A.
74
77.1
N.A.
N.A.
P-Site Identity:
100
100
93.3
100
N.A.
86.6
86.6
N.A.
N.A.
86.6
86.6
80
N.A.
66.6
73.3
N.A.
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
86.6
86.6
N.A.
N.A.
93.3
93.3
86.6
N.A.
80
86.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.8
58
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.6
72.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
73.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
24
0
8
0
16
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
70
0
0
0
0
% C
% Asp:
8
0
0
93
0
39
0
8
0
0
0
0
0
0
8
% D
% Glu:
0
8
0
0
0
16
8
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
85
0
93
0
0
0
0
16
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
54
0
93
0
% K
% Leu:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
24
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
93
0
0
0
0
0
0
0
0
0
0
85
0
62
% P
% Gln:
0
0
0
8
0
8
0
0
0
0
24
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
93
0
0
0
0
0
0
% R
% Ser:
0
0
93
0
0
0
0
85
0
70
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
93
0
0
0
8
8
0
0
0
0
0
16
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _