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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD1 All Species: 35.45
Human Site: S594 Identified Species: 65
UniProt: P11586 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11586 NP_005947.3 935 101559 S594 G K M V V A S S K K G E P V S
Chimpanzee Pan troglodytes XP_001170520 978 105642 S650 G K M V V A S S K K G E P V S
Rhesus Macaque Macaca mulatta XP_001101889 921 99498 S593 G K M V V A S S K K G E P V S
Dog Lupus familis XP_537476 935 101232 S594 S K M V V A S S K K G E P I S
Cat Felis silvestris
Mouse Mus musculus Q922D8 935 101237 S594 G R M V V A S S K K G E P I S
Rat Rattus norvegicus P27653 935 100977 S594 G K M V V A S S K K G E P I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034392 935 100213 S594 G R M V V A S S K R G E P V T
Frog Xenopus laevis NP_001080574 934 100531 S593 G K M V V A S S K K G E P V S
Zebra Danio Brachydanio rerio NP_955823 934 100443 S593 A K M V V A T S R S G Q P V T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96553 968 103485 D627 A D M V V A F D K R G K P V T
Honey Bee Apis mellifera XP_623070 937 101449 N596 G N I V V A F N K N G E P L T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPK5 634 67783 P330 M Q T L E G T P V L V H A G P
Baker's Yeast Sacchar. cerevisiae P07245 946 102187 D599 G R V V V A A D V N R S P V T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.6 94.7 94.4 N.A. 92.8 93.3 N.A. N.A. 80.7 82.3 76.9 N.A. 59.8 62.4 N.A. N.A.
Protein Similarity: 100 93.4 96.6 97.7 N.A. 97.7 97.4 N.A. N.A. 91.3 92.8 88.3 N.A. 74 77.1 N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 86.6 93.3 N.A. N.A. 80 100 60 N.A. 53.3 53.3 N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 100 100 86.6 N.A. 73.3 80 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 46.8 58 N.A.
Protein Similarity: N.A. N.A. N.A. 55.6 72.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 40 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 0 0 0 0 93 8 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 16 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 0 0 70 0 0 0 % E
% Phe: 0 0 0 0 0 0 16 0 0 0 0 0 0 0 0 % F
% Gly: 70 0 0 0 0 8 0 0 0 0 85 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 0 0 24 0 % I
% Lys: 0 54 0 0 0 0 0 0 77 54 0 8 0 0 0 % K
% Leu: 0 0 0 8 0 0 0 0 0 8 0 0 0 8 0 % L
% Met: 8 0 77 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 8 0 16 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 8 0 0 0 0 93 0 8 % P
% Gln: 0 8 0 0 0 0 0 0 0 0 0 8 0 0 0 % Q
% Arg: 0 24 0 0 0 0 0 0 8 16 8 0 0 0 0 % R
% Ser: 8 0 0 0 0 0 62 70 0 8 0 8 0 0 54 % S
% Thr: 0 0 8 0 0 0 16 0 0 0 0 0 0 0 39 % T
% Val: 0 0 8 93 93 0 0 0 16 0 8 0 0 62 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _