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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1
All Species:
30.61
Human Site:
S736
Identified Species:
56.11
UniProt:
P11586
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11586
NP_005947.3
935
101559
S736
E
L
V
E
K
G
F
S
N
L
K
K
Q
I
E
Chimpanzee
Pan troglodytes
XP_001170520
978
105642
S792
E
L
V
E
K
G
F
S
N
L
K
K
Q
I
E
Rhesus Macaque
Macaca mulatta
XP_001101889
921
99498
S735
E
L
V
E
K
G
F
S
N
L
K
K
Q
I
E
Dog
Lupus familis
XP_537476
935
101232
S736
E
L
V
E
K
G
F
S
N
L
K
K
Q
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q922D8
935
101237
S736
D
L
V
E
K
G
F
S
N
L
R
K
Q
I
E
Rat
Rattus norvegicus
P27653
935
100977
S736
D
L
V
E
K
G
F
S
N
L
R
K
Q
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034392
935
100213
S736
Q
L
L
A
K
G
C
S
N
L
S
K
Q
I
Q
Frog
Xenopus laevis
NP_001080574
934
100531
S735
D
L
I
E
K
G
C
S
N
L
R
K
Q
I
E
Zebra Danio
Brachydanio rerio
NP_955823
934
100443
A735
T
L
L
E
A
G
C
A
N
M
R
K
Q
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
P769
E
L
V
Q
K
G
L
P
N
L
L
Q
H
I
E
Honey Bee
Apis mellifera
XP_623070
937
101449
P738
D
L
I
R
K
G
L
P
N
L
Q
K
H
I
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
D461
A
V
N
M
F
A
T
D
T
E
A
E
L
N
A
Baker's Yeast
Sacchar. cerevisiae
P07245
946
102187
A748
E
F
V
E
K
G
A
A
N
M
C
K
Q
I
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
94.7
94.4
N.A.
92.8
93.3
N.A.
N.A.
80.7
82.3
76.9
N.A.
59.8
62.4
N.A.
N.A.
Protein Similarity:
100
93.4
96.6
97.7
N.A.
97.7
97.4
N.A.
N.A.
91.3
92.8
88.3
N.A.
74
77.1
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
N.A.
60
73.3
46.6
N.A.
60
46.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
80
93.3
80
N.A.
73.3
66.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.8
58
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.6
72.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
8
8
8
16
0
0
8
0
0
0
16
% A
% Cys:
0
0
0
0
0
0
24
0
0
0
8
0
0
0
0
% C
% Asp:
31
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
47
0
0
70
0
0
0
0
0
8
0
8
0
0
70
% E
% Phe:
0
8
0
0
8
0
47
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
93
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
0
% H
% Ile:
0
0
16
0
0
0
0
0
0
0
0
0
0
85
0
% I
% Lys:
0
0
0
0
85
0
0
0
0
0
31
85
0
0
0
% K
% Leu:
0
85
16
0
0
0
16
0
0
77
8
0
8
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
16
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
0
0
93
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
8
0
0
0
0
0
0
8
8
77
0
8
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
31
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
62
0
0
8
0
0
0
8
% S
% Thr:
8
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% T
% Val:
0
8
62
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _