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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFD1
All Species:
17.88
Human Site:
S774
Identified Species:
32.78
UniProt:
P11586
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11586
NP_005947.3
935
101559
S774
L
D
L
I
S
R
L
S
R
E
H
G
A
F
D
Chimpanzee
Pan troglodytes
XP_001170520
978
105642
S830
L
D
L
I
S
R
L
S
R
E
H
G
A
F
D
Rhesus Macaque
Macaca mulatta
XP_001101889
921
99498
S773
L
D
L
I
S
R
L
S
R
E
H
G
A
F
D
Dog
Lupus familis
XP_537476
935
101232
A774
L
D
L
V
S
R
L
A
K
E
H
G
A
F
D
Cat
Felis silvestris
Mouse
Mus musculus
Q922D8
935
101237
S774
L
D
L
V
S
R
L
S
R
E
H
G
A
F
D
Rat
Rattus norvegicus
P27653
935
100977
S774
L
D
L
I
G
R
L
S
R
E
H
G
A
F
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001034392
935
100213
A774
L
A
L
V
V
Q
L
A
K
E
A
G
A
F
D
Frog
Xenopus laevis
NP_001080574
934
100531
A773
L
D
I
V
C
D
L
A
K
K
A
G
A
F
D
Zebra Danio
Brachydanio rerio
NP_955823
934
100443
A773
L
N
L
I
C
K
M
A
K
E
A
G
A
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O96553
968
103485
A807
H
E
L
V
K
K
A
A
L
E
A
G
A
F
A
Honey Bee
Apis mellifera
XP_623070
937
101449
A776
L
E
L
I
K
E
A
A
I
K
S
G
A
I
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SPK5
634
67783
H489
V
V
C
S
H
H
A
H
S
G
K
G
A
V
D
Baker's Yeast
Sacchar. cerevisiae
P07245
946
102187
A786
I
A
A
I
R
K
A
A
L
E
A
G
A
F
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
94.7
94.4
N.A.
92.8
93.3
N.A.
N.A.
80.7
82.3
76.9
N.A.
59.8
62.4
N.A.
N.A.
Protein Similarity:
100
93.4
96.6
97.7
N.A.
97.7
97.4
N.A.
N.A.
91.3
92.8
88.3
N.A.
74
77.1
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
93.3
93.3
N.A.
N.A.
53.3
46.6
53.3
N.A.
33.3
40
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
80
80
86.6
N.A.
60
60
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.8
58
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.6
72.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
8
0
0
0
31
54
0
0
39
0
100
0
8
% A
% Cys:
0
0
8
0
16
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
54
0
0
0
8
0
0
0
0
0
0
0
0
85
% D
% Glu:
0
16
0
0
0
8
0
0
0
77
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
85
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
8
0
100
0
0
0
% G
% His:
8
0
0
0
8
8
0
8
0
0
47
0
0
0
0
% H
% Ile:
8
0
8
54
0
0
0
0
8
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
16
24
0
0
31
16
8
0
0
0
0
% K
% Leu:
77
0
77
0
0
0
62
0
16
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
47
0
0
39
0
0
0
0
0
0
% R
% Ser:
0
0
0
8
39
0
0
39
8
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
8
0
39
8
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _