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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD1 All Species: 27.58
Human Site: S87 Identified Species: 50.56
UniProt: P11586 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11586 NP_005947.3 935 101559 S87 E V M K Y I T S L N E D S T V
Chimpanzee Pan troglodytes XP_001170520 978 105642 S143 E V M K Y I T S L N E D S T V
Rhesus Macaque Macaca mulatta XP_001101889 921 99498 S87 E V I K Y I T S L N E D S T I
Dog Lupus familis XP_537476 935 101232 S87 E V L K Y V T S L N E D L T V
Cat Felis silvestris
Mouse Mus musculus Q922D8 935 101237 S87 E V L K Y V I S L N E D A S V
Rat Rattus norvegicus P27653 935 100977 S87 E V L K Y V I S L N E D A T V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034392 935 100213 S87 E V L K C I A S L N G D P A V
Frog Xenopus laevis NP_001080574 934 100531 S86 E V L S K I M S I N E D P A Y
Zebra Danio Brachydanio rerio NP_955823 934 100443 E86 E V L Q S V T E V N E N S K I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96553 968 103485 D121 E L L D K I N D L N E D P R V
Honey Bee Apis mellifera XP_623070 937 101449 K90 E L I N K V N K L N Q D P N I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPK5 634 67783
Baker's Yeast Sacchar. cerevisiae P07245 946 102187 Q86 E V L R Y V D Q L N E D P H T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.6 94.7 94.4 N.A. 92.8 93.3 N.A. N.A. 80.7 82.3 76.9 N.A. 59.8 62.4 N.A. N.A.
Protein Similarity: 100 93.4 96.6 97.7 N.A. 97.7 97.4 N.A. N.A. 91.3 92.8 88.3 N.A. 74 77.1 N.A. N.A.
P-Site Identity: 100 100 86.6 80 N.A. 66.6 73.3 N.A. N.A. 60 46.6 40 N.A. 46.6 26.6 N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. N.A. 66.6 60 80 N.A. 60 60 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 46.8 58 N.A.
Protein Similarity: N.A. N.A. N.A. 55.6 72.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 8 0 0 0 0 0 16 16 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 8 8 0 0 0 85 0 0 0 % D
% Glu: 93 0 0 0 0 0 0 8 0 0 77 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 16 0 0 47 16 0 8 0 0 0 0 0 24 % I
% Lys: 0 0 0 54 24 0 0 8 0 0 0 0 0 8 0 % K
% Leu: 0 16 62 0 0 0 0 0 77 0 0 0 8 0 0 % L
% Met: 0 0 16 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 16 0 0 93 0 8 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 39 0 0 % P
% Gln: 0 0 0 8 0 0 0 8 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 0 % R
% Ser: 0 0 0 8 8 0 0 62 0 0 0 0 31 8 0 % S
% Thr: 0 0 0 0 0 0 39 0 0 0 0 0 0 39 8 % T
% Val: 0 77 0 0 0 47 0 0 8 0 0 0 0 0 54 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 54 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _