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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFD1 All Species: 28.79
Human Site: T509 Identified Species: 52.78
UniProt: P11586 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P11586 NP_005947.3 935 101559 T509 I E K T D P T T L T D E E I N
Chimpanzee Pan troglodytes XP_001170520 978 105642 T565 I E K T D P T T L T D E E I N
Rhesus Macaque Macaca mulatta XP_001101889 921 99498 T508 I E K T D P T T L T D E E I N
Dog Lupus familis XP_537476 935 101232 T509 I E K T D P T T L T D D E I N
Cat Felis silvestris
Mouse Mus musculus Q922D8 935 101237 T509 I E K T D P T T L T D D E I N
Rat Rattus norvegicus P27653 935 100977 A509 I E K T D P A A L T D D E I N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001034392 935 100213 A509 I S K T D P A A L T K E E V N
Frog Xenopus laevis NP_001080574 934 100531 A508 I E K T D P A A L T E E E I N
Zebra Danio Brachydanio rerio NP_955823 934 100443 T508 I K K T D P S T L T E E E I T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O96553 968 103485 T542 I T K T D P D T L T A D E Y G
Honey Bee Apis mellifera XP_623070 937 101449 S511 I T K T D P N S L T E E E K R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SPK5 634 67783 G246 F L R K I T I G Q G P E E K G
Baker's Yeast Sacchar. cerevisiae P07245 946 102187 D514 I Q K T N P D D L T P E E I N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.6 94.7 94.4 N.A. 92.8 93.3 N.A. N.A. 80.7 82.3 76.9 N.A. 59.8 62.4 N.A. N.A.
Protein Similarity: 100 93.4 96.6 97.7 N.A. 97.7 97.4 N.A. N.A. 91.3 92.8 88.3 N.A. 74 77.1 N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 93.3 80 N.A. N.A. 66.6 80 73.3 N.A. 60 60 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 86.6 N.A. N.A. 73.3 86.6 93.3 N.A. 66.6 73.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 46.8 58 N.A.
Protein Similarity: N.A. N.A. N.A. 55.6 72.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 24 24 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 85 0 16 8 0 0 47 31 0 0 0 % D
% Glu: 0 54 0 0 0 0 0 0 0 0 24 70 100 0 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 16 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 93 0 0 0 8 0 8 0 0 0 0 0 0 70 0 % I
% Lys: 0 8 93 8 0 0 0 0 0 0 8 0 0 16 0 % K
% Leu: 0 8 0 0 0 0 0 0 93 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 70 % N
% Pro: 0 0 0 0 0 93 0 0 0 0 16 0 0 0 0 % P
% Gln: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % Q
% Arg: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 8 % R
% Ser: 0 8 0 0 0 0 8 8 0 0 0 0 0 0 0 % S
% Thr: 0 16 0 93 0 8 39 54 0 93 0 0 0 0 8 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _